Results 151 to 160 of about 476,055 (308)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Speed of convergence in global value chains: Forward or backward linkage. [PDF]

Heliyon, 2023
Wuri J, Widodo T, Hardi AS.
europepmc   +1 more source

Food chains and value system: the case of potato, fruit, and cheese

The aim of the paper is to analyse patterns of value system sharing along food chains, so to explore the agro-food enterprises capacity to be competitive and sustainable.
Rivaroli, Sergio, Bertazzoli, Aldo, Fiorini, A., Samoggia, Antonella, Ghelfi, Rino, Mazzotti, V.   +5 more
core  

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

The impact of trade on employment: New evidence from a global value chains perspective. [PDF]

PLoS One, 2023
Mingyang Y, Hankun Y, Chen X, Zhida J.
europepmc   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Tracing metal footprints via global renewable power value chains. [PDF]

Nat Commun, 2023
Fu R, Peng K, Wang P, Zhong H, Chen B, Zhang P, Zhang Y, Chen D, Liu X, Feng K, Li J.   +10 more
europepmc   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Identification of Marine Biotechnology Value Chains with High Potential in the Northern Mediterranean Region. [PDF]

Mar Drugs, 2023
Rotter A, Giannakourou A, Argente García JE, Quero GM, Auregan C, Triantaphyllidis G, Venetsanopoulou A, De Carolis R, Efstratiou C, Aboal M, Abad MÁE, Grigalionyte-Bembič E, Kotzamanis Y, Kovač M, Ljubić Čmelar M, Luna GM, Aguilera C, Acién Fernández FG, Gómez Pinchetti JL, Manzo S, Milašinčić I, Nadarmija A, Parrella L, Pinat M, Roussos E, Ruel C, Salvatori E, Sánchez Vázquez FJ, Semitiel García M, Skarmeta Gómez AF, Ulčar J, Chiavetta C.   +31 more
europepmc   +1 more source

Power Relationships along the Value Chain: Multinational Firms, Global Buyers, and Local Suppliers' Performance [PDF]

There is an growing literature exploring the increasing fragmentation of production processes and the evolution of internationally-dispersed but functionally-integrated economic activities. However, most of this literature appears to neglect an important
Carlo Pietrobelli, Federica Saliola
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