MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Customer value drivers in business markets: Perceptions by purchasing professionals
, 2009 Customer value is a complex phenomenon, which has been researched from various perspectives. Although many studies have suggested different sets of values, few papers presented structured models of customer value drivers.
SYTNIKOV, EVGENI
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Co-Design of a Theory-Informed, Multicomponent, Intervention for Diagnostic Stewardship in a Major-Referral Emergency Department: A Qualitative Descriptive Study. [PDF]
Emerg Med AustralasGangathimmaiah V +3 more
europepmc +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Customer value drivers in business markets: Perceptions by purchasing professionals [PDF]
Customer value is a complex phenomenon, which has been researched from various perspectives. Although many studies have suggested different sets of values, few papers presented structured models of customer value drivers.
SYTNIKOV, EVGENI
core
Using Progressive Muscle Relaxation for Reducing Fatigue among Truck Drivers
JHE: Journal of Health EducationBackground: Long working hours, poor working conditions, and irregular sleep patterns increase the risk of burnout in freight truck drivers. Progressive muscle relaxation (PMR) is a procedure to relax muscles.
Santy Deasy Siregar +6 more
doaj
Conflict with industrial fleets undermines the contributions of small-scale fisheries to sustainable development in vulnerable regions. [PDF]
Nat FoodCronin MR +8 more
europepmc +1 more source