Results 181 to 190 of about 6,364,896 (296)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Scientific basis and applicability of the ISO 2631-1 health guidance caution zone. [PDF]

Int Arch Occup Environ Health
Tarabini M, Williams G, Smith S, Maeda S, Bovenzi M.   +4 more
europepmc   +1 more source

Circular economy value drivers

This report will provide a comprehensive study of circular economy business value drivers and their potential for value creation.
openaire   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Correlates of unsafe driving in non-professional drivers: insights from a data-driven modeling approach. [PDF]

J Egypt Public Health Assoc
Abdolrazaghi A, Mirzahossein H.
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Association between dynamic changes in lumbar back temperature during professional driver training and lumbar muscle endurance: a longitudinal study. [PDF]

Front Physiol
Sang X, Yi L, Tian Y, Wang Z, Sun C, Wang X, Gu W.   +6 more
europepmc   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

lncAPNet enables the deciphering of lncRNA-mRNA connections in patient transcriptomic data. [PDF]

Bioinform Adv
Vasileiou V, Gavriilidis GI, Zeni PF, Mraz M, Karatzas E, Giakountis A, Pavlopoulos GA, Giannakakis A, Psomopoulos F.   +8 more
europepmc   +1 more source

DRIVERS OF ORGANIZATION VALUE CREATION

Вестник Алтайской академии экономики и права
N.A. Wybornov, M.Yu. Makovetsky, S.N. Markov   +2 more
openaire   +1 more source