Results 111 to 120 of about 4,889,999 (350)

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

open access: yesMolecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian   +10 more
wiley   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

open access: yesMolecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath   +13 more
wiley   +1 more source

Synergizing BIM and Value Engineering in the Construction of Residential Projects: A Novel Integration Framework

open access: yesBuildings
This study explores integrating Building Information Modeling (BIM) and Value Engineering (VE) to enhance cost management and project value optimization in residential construction.
Ahmed Gouda Mohamed   +3 more
doaj   +1 more source

Extreme Value Theory for Tail-Related Risk Measures [PDF]

open access: yes
Many fields of modern science and engineering have to deal with events which are rare but have significant consequences. Extreme value theory is considered to provide the basis for the statistical modeling of such extremes. The potential of extreme value
Evis Këllezi, Manfred Gilli
core  

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

open access: yesMolecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy   +9 more
wiley   +1 more source

Provide a model of the impact of Value Engineering and Organizational Agility in improving the competitiveness of construction industry companies [PDF]

open access: yesمهندسی و مدیریت ساخت, 2018
The increasing speed of changes in technologies and markets and in customers nature and on the other hand the intensifying competition between organizations, has led companies to intensively seek new competitive advantages to excel among competitors and ...
Mohammad Jahankohan   +1 more
doaj  

Application of NASA ERTS-1 satellite imagery in coastal studies [PDF]

open access: yes
There are no author-identified significant results in this report. Review of ERTS-1 imagery indicates that it contains information of great value in coastal engineering studies.
Berg, D. W.   +2 more
core   +1 more source

Fault Localization Models in Debugging

open access: yes, 2018
Debugging is considered as a rigorous but important feature of software engineering process. Since more than a decade, the software engineering research community is exploring different techniques for removal of faults from programs but it is quite ...
Alansari, Zainab   +3 more
core   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

open access: yesMolecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster   +3 more
wiley   +1 more source

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