Results 121 to 130 of about 4,902,162 (302)
Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
SystemsIntelligent driving technology is expected to reshape urban transportation, but its promotion is hindered by user acceptance challenges and diverse technical routes. This study proposes a comprehensive user acceptance evaluation framework for intelligent
Wang Zhang +4 more
doaj +1 more source
PVEX: An expert system for producibility/value engineering [PDF]
PVEX is described as an expert system that solves the problem of selection of the material and process in missile manufacturing. The producibility and the value problem has been deeply studied in the past years, and was written in dBase III and PROLOG ...
Lam, Chun S., Moseley, Warren
core +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Value Creation and Value Capture at Manufacturing Firms : Importance of Non-functional Value [PDF]
Most large Japanese manufacturers are good at creating value utilizing their engineering capabilities but poor at capturing value in terms of creating profit and added value.
Nobeoka, Kentaro
core
PENERAPAN VALUE ENGINEERINGRNRNPADA PEKERJAAN BANGU NAN BAWAHRNRNPENGGANDAAN JEMBATAN LAMNYONG BANDA ACEH [PDF]
, 2015 PENERAPAN VALUE ENGINEERING PADA PEKERJAAN BANGUNAN BAWAH PENGGANDAAN JEMBATAN LAMNYONG BANDA ACEH Oleh JOHNNERI FERDIAN NIM : 1309200060016 Komisi Pembimbing: 1. Dr. Ir. M. Isya, MT 2. Dr. Hafnidar A. Rani, ST. MM ABSTRAK Penelitian ini dilakukan
JOHNNERI FERDIAN
core
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Systems integrated human engineering on the Navy's rapid acquisition of manufactured parts/test and integration facility [PDF]
Human Engineering in many projects is at best a limited support function. In this Navy project the Human Engineering function is an integral component of the systems design and development process.
Gallaway, Glen R.
core +1 more source