Results 121 to 130 of about 173,709,671 (285)
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
, 2010 application/pdf; "July 2010.""The Division of Information Systems and Communications, also known as DISC, is a fee-based organization comprised of seven operational units that deliver 24 x 7 central information technology services such as statewide data,
Kansas. Department of Administration. Division of Information Systems and Communications.
core +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
, 2009 application/pdf; "July 2009.""The Division of Information Systems and Communications, also known as DISC, is a fee-based organization comprised of seven operational units that deliver 24 x 7 central information technology services such as statewide data,
Kansas. Department of Administration. Division of Information Systems and Communications.
core +1 more source
Value-of-Information Analysis for External Validation of Risk Prediction Models. [PDF]
Med Decis Making, 2023 Sadatsafavi M +4 more
europepmc +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Department of Information and Technology Solutions newsletter February 2021
, 2021 The Department of Information and Technology Solutions changed its name in December 2023 to the Department of Information Technology. In July 2019, the Department of Computing, Communications, and Information Technologies (CCIT) changed its name to the ...
core
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
The role and value of ethical frameworks in software development [PDF]
, 2003 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Software development is notorious for failure, typically defined as over budget, late delivery and/or poor quality of new information systems (IS) on ...
Dodd, Sean
core +2 more sources