Results 191 to 200 of about 960,840 (259)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Usability, Relevance, and User Engagement of a Government-Sponsored and Community Co-Designed Digital Mental Health Website During the COVID-19 Pandemic: A Pilot Study on Latino/a/x Adults. [PDF]

JMIR Form Res
Wright B, Zhang L, Meza JI, Rodriguez L, Contreras I, Terán V, Young AS, Nuño M, Dzou T, Aguilar-Gaxiola S, Wells KB.   +10 more
europepmc   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Challenges underlying radiology's research problem. [PDF]

Insights Imaging
Martí-Bonmatí L, Pinto Dos Santos D, Veiga-Canuto D, Loewe C.   +3 more
europepmc   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Comment on "Correlation Analysis of 24-h Minimum Heart Rate Levels and Deceleration Capacity of Heart Rate in Patients With Type 2 Diabetes Mellitus Complicated With Essential Hypertension". [PDF]

Ann Noninvasive Electrocardiol
Naveed M, Naveed M, Ahmed I, Sajjad M, Jan M.   +4 more
europepmc   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

An <i>in silico</i> bioinformatics framework for prioritizing candidate genes in the coronary no-reflow phenomenon. [PDF]

Glob Cardiol Sci Pract
Rahman FA, Suryono S, Maulana AS, Wulandari P.   +3 more
europepmc   +1 more source

Assessment of the learning environment among medical students at Tabuk University, Saudi Arabia: a cross-sectional study. [PDF]

Front Med (Lausanne)
Altowijri AA.
europepmc   +1 more source

Exploring transdiagnostic factors for mental health screening in primary care: a secondary analysis of a randomised controlled pilot study. [PDF]

BMC Res Notes
Ebert C, Peris-Baquero Ó, Junker L, Ehring T, Gensichen J, Osma J, POKAL-Group.   +6 more
europepmc   +1 more source