Results 131 to 140 of about 13,432,161 (307)
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Predicting extreme VaR: Nonparametric quantile regression with refinements from extreme value theory [PDF]
This paper studies the performance of nonparametric quantile regression as a tool to predict Value at Risk (VaR). The approach is flexible as it requires no assumptions on the form of return distributions.
Julia Schaumburg
core
Drought risk probabilistic models based on extreme value theory. [PDF]
Environ Sci Pollut Res Int, 2023 Piwowar A, Kuźmiński Ł.
europepmc +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
, 2015 This chapter discusses time and value. The two main questions are: What is the time of value? and What is the value of time? The first main question splits into two: Does what has value always have a temporal location? and Does value itself have temporal
Bykvist, Krister,
core +1 more source
Gradient boosting with extreme-value theory for wildfire prediction. [PDF]
Extremes (Boston), 2023 Koh J.
europepmc +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Editorial - Guest editors' introduction to a special issue on value theory
, 2009 This is an introduction to a special issue of Ethical Theory and Moral Practice that deals with various aspects of value ...
Mulligan, Kevin +2 more
core
Towards the Anthropological Theory of Value
Etnoantropološki Problemi, 2019 Graeber, David. 2016. Prema antropološkoj teoriji vrijednosti: lažna kovanica naših snova.
Radmila Balaban
doaj