Results 91 to 100 of about 21,674,610 (304)

The model theory of separably tame valued fields [PDF]

open access: yes, 2014
A henselian valued field $K$ is called separably tame if its separable-algebraic closure $K^{\operatorname{sep}}$ is a tame extension, that is, the ramification field of the normal extension $K^{\operatorname{sep}}|K$ is separable-algebraically closed ...
F. Kuhlmann, K. Pal
semanticscholar   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Hermite–Hadamard-Mercer Type Inequalities for Interval-Valued Coordinated Convex Functions

open access: yesAxioms
Determining the Jensen–Mercer inequality for interval-valued coordinated convex functions has been a challenging task for researchers in the fields of inequalities and interval analysis.
Muhammad Toseef   +3 more
doaj   +1 more source

Field-Sensitive Value Analysis by Field-Insensitive Analysis [PDF]

open access: yes, 2009
Shared and mutable data-structures pose major problems in static analysis and most analyzers are unable to keep track of the values of numeric variables stored in the heap. In this paper, we first identify sufficient conditions under which heap allocated numeric variables in object oriented programs (i.e., numeric fields) can be handled as non-heap ...
Albert E.   +3 more
openaire   +2 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Pulse percolation conduction and multi-valued memory

open access: yesAIP Advances, 2020
We develop a theory of pulse conduction in percolation type materials such as noncrystalline semiconductors and nano-metal compounds. For short voltage pulses, the corresponding electric currents are inversely proportional to the pulse length and exhibit
V. G. Karpov   +3 more
doaj   +1 more source

Microlocal Geometry and Valued Fields

open access: yesPublications of the Research Institute for Mathematical Sciences, 2011
This is an overview of some recent connections between non-archimedean geometry and microlocal analysis, with some emphasis on the motivic Milnor fiber and the properties of tangent cones.
openaire   +3 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

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