Results 121 to 130 of about 983,670 (345)

Organ‐Specific and Conserved Regulatory Logic Orchestrates Gene Expression in the Embryonic Mesothelium

Advanced Science, EarlyView.
Integrated multi‐omic profiling maps the gene‐regulatory landscape of the coelomic mesothelium across heart, lung, and pancreas. A cardiac‐restricted regulatory program is uncovered in which TBX20 activates heart mesothelial (epicardial) cis‐regulatory elements, while MAF emerges as a conserved regulator of mesothelial identity.
Quang Minh Dang, Nicola Smart, Andia Nicole Redpath, Joaquim Miguel Vieira   +3 more
wiley   +1 more source

Endothelial GPR68 Is Essential for Arteriogenesis and Represents a Therapeutic Target in a Model of Peripheral Artery Disease

Advanced Science, EarlyView.
Endothelial GPR68 is identified as a critical regulator of collateral artery growth in peripheral artery disease. Genetic and pharmacological evidence demonstrates that GPR68 integrates hemodynamic cues to drive monocyte recruitment and inflammatory remodeling, thereby promoting collateral arteriogenesis and tissue perfusion after ischemia ...
Yiyan Song, Senyi Peng, Zhilei Huang, Miao Yu, Mingyue Wu, Yuexin Zhu, Zeyi Zhou, Yongshan Liu, Yalin Zhang, Yu Huang, Zhongxing Wang, Fu‐Li Xiang, Jie Xu   +12 more
wiley   +1 more source

A Long-Term Prognosis of Adaptive Servo Ventilation Therapy for Patients with Heart Failure -Consideration in Severity of Sleep-Disordered Breathing- [PDF]

, 2019
学位記番号 ...
Goto, Keita, ゴトウ, ケイタ, 後藤, 慶大   +2 more
core   +1 more source

Material transport in the left ventricle with aortic valve regurgitation

, 2018
This experimental in vitro work investigates material transport properties in a model left ventricle in the case of aortic regurgitation, a valvular disease characterized by a leaking aortic valve and consequently double-jet filling within the elastic ...
Di Labbio, Giuseppe, Kadem, Lyes, Vétel, Jérôme   +2 more
core   +1 more source

Clinical Severity Score System in Dogs with Degenerative Mitral Valve Disease [PDF]

, 2015
BACKGROUND: Several risk factors already have been determined for dogs with degenerative mitral valve disease (DMVD). Risk factors often have been considered in isolation and have not always taken into account additional information provided by the ...
Atkins, Borgarelli, Borgarelli, Borgarelli, Boswood, Boswood, Chetboul, DeFrancesco, Doxey, Ferasin, Fujii, Gill, Haggstrom, Haggstrom, Haggstrom, Haggstrom, Haggstrom, Haggstrom, Hezzell, Kittleson, Ljungvall, Lord, López-Alvarez, Miller, Moonarmart, Ohad, Olsen, Pedersen, Pedersen, Reynolds, Schober, Tarnow   +31 more
core   +2 more sources

Selective Inhibition of Integrin β3 Topology Provides a Safer Antithrombotic Strategy

Advanced Science, EarlyView.
Current integrin αIIbβ3 inhibitors effectively reduce thrombosis but also increase bleeding risk. During thrombosis, high shear blood flow can directly activate the integrin αIIbβ3 via a distinct topological change in the β3 transmembrane domain, independent of hemostatic platelet signaling.
Joonha Lee, Chul‐Gyun Lim, Pothiappan Vairaprakash, Jong‐Min Kim, Jiyoon Kim, Ji‐Young Park, Klaus M. Hahn, Hyunbo Shim, Hae Woong Choi, Tobias S. Ulmer, Soon Jun Hong, Chungho Kim   +11 more
wiley   +1 more source

A Novel A‐Kinase‐Anchoring Protein 9 Variant in Premature Coronary Artery Disease: A Case Series

Molecular Genetics & Genomic Medicine
Background Familial premature coronary artery disease (CAD) is often associated with genetic variants. This study investigated potential causal variants in a Chinese pedigree with premature CAD.
Yuemiao Jiao, Minxian Wang, Guifen Qiang, Li Zhao, Ziwei Xi, Yue Yu, Chengqian Yin, Guangyuan Song   +7 more
doaj   +1 more source

Rationale and design of SCOPE trial: a prospective, multicentre, open-label, randomised controlled trial to evaluate the overall efficacy and safety of a short-term anticoagulation strategy versus conventional single antiplatelet therapy in patients with severe aortic stenosis without indications for anticoagulation or dual antiplatelet therapy post-transcatheter aortic valve replacement

BMJ Open
Introduction While transcatheter aortic valve replacement (TAVR) has become a well-established standard of care for patients with symptomatic severe aortic stenosis, the optimal antithrombotic strategy post-TAVR remains a subject of debate, particularly ...
Yang Wang, Yan Li, Lihua Zhang, Ran Liu, Wei Wu, Yang Li, Huiping Zhang, Stuart Pocock, Xinmin Liu, Zhinan Lu, Taiyang Luo, Liang Guo, Fei Yuan, Yi-Da Tang, Yingxuan Zhu, Yunfeng Yan, Guangyuan Song, Zhengming Jiang, SCOPE Investigators   +18 more
doaj   +1 more source

Transition in Patients with Congenital Heart Disease in Germany: Results of a Nationwide Patient Survey

Frontiers in Pediatrics, 2017
BackgroundA growing number of adults with congenital heart disease (ACHD) pose a particular challenge for health care systems across the world. Upon turning into 18 years, under the German national health care system, ACHD patients are required to switch
Paul C. Helm, Paul C. Helm, Harald Kaemmerer, Günter Breithardt, Günter Breithardt, Elisabeth J. Sticker, Roland Keuchen, Rhoia Neidenbach, Gerhard-Paul Diller, Gerhard-Paul Diller, Oktay Tutarel, Ulrike M. M. Bauer, Ulrike M. M. Bauer, Ulrike M. M. Bauer   +13 more
doaj   +1 more source

Possible predicative role of electrical risk score on transcatheter aortic valve replacement outcomes in older patients. preliminary data [PDF]

, 2018
Background:Transcatheter aortic valve replacement (TAVR) is an effective procedure capable to change the natural history of the degenerative aortic valve stenosis.
DI IORIO, Claudia, Fabietti, Marcella, Magri', Damiano, Mancone, Massimo, Mariani, MARCO VALERIO, Mastropietri, Fabiola, Moscucci, Federica, Parrotta, Ilaria, Piccirillo, Gianfranco, Sardella, Gennaro   +9 more
core   +1 more source