Results 251 to 260 of about 881,500 (386)

Pediatric Developmental Safety Assessment: Are We Ready for the Next Thalidomide?

Clinical Pharmacology &Therapeutics, EarlyView.
Pediatric drug development has achieved remarkable success in the last 20 years with over 1,000 products studied in pediatric patients. This success has been driven in part by an increased understanding of pediatric disease processes. The aspect that has been largely overlooked is the potential adverse effect of new drugs on pediatric developmental ...
Gilbert J. Burckart, Susan M. Abdel‐Rahman, Gelareh Abulwerdi, Sherbet Samuels, Rebecca Racz, Mohamed A. Mohamoud, Nicholas P. Tatonetti   +6 more
wiley   +1 more source

The Valvular Heart Disease in Women (VHD-W) Registry: a global initiative to address gender disparities in management and outcomes. [PDF]

Eur Heart J Imaging Methods Pract
Anwer S, Perez-Lopez P, Elzieny AA, Hosseini N, Neglia D, Timoteo AT, Petersen SE, Delgado V, Gimelli A, Almeida AG, Grapsa J.   +10 more
europepmc   +1 more source

Lineage labeling with zebrafish hand2 Cre and CreERT2 recombinase CRISPR knock‐ins

Developmental Dynamics, EarlyView.
Abstract Background The ability to generate endogenous Cre recombinase drivers using CRISPR‐Cas9 knock‐in technology allows lineage tracing, cell type‐specific gene studies, and in vivo validation of inferred developmental trajectories from phenotypic and gene expression analyses. This report describes endogenous zebrafish hand2 Cre and CreERT2 drivers
Zhitao Ming, Fang Liu, Hannah R. Moran, Robert L. Lalonde, Megan Adams, Nicole K. Restrepo, Parnal Joshi, Stephen C. Ekker, Karl J. Clark, Iddo Friedberg, Saulius Sumanas, Chunyue Yin, Christian Mosimann, Jeffrey J. Essner, Maura McGrail   +14 more
wiley   +1 more source

Anticoagulation in Atrial Fibrillation With Valvular Heart Disease. [PDF]

J Am Heart Assoc
Fonseca AC, Jorge C.
europepmc   +1 more source

Association of COPD with adverse outcomes in heart failure patients with preserved ejection fraction

ESC Heart Failure, Volume 12, Issue 2, Page 799-808, April 2025.
Abstract We performed a systematic review and meta‐analysis to detect the impact of chronic obstructive pulmonary disease (COPD) on the prognosis of heart failure patients with preserved ejection fraction (HFpEF). We systematically screened eligible literature from three electronic databases, PubMed, EMBASE and Cochrane Library, up to April 2023.
Shuo Xu, Zhenbang Gu, Wengen Zhu, Shenghui Feng   +3 more
wiley   +1 more source

Association of Non-Insulin-Based Insulin Resistance Indices With Risk of Incident Valvular Heart Disease: Results From the UK Biobank Cohort Study. [PDF]

J Am Heart Assoc
Zhang Z, Guo C, Hu X, Li Y, Han S, Liu X, Li P, Zhu H, Liu Z, Guo J.   +9 more
europepmc   +1 more source

Guidelines for the Diagnosis and Treatment of Canine Chronic Valvular Heart Disease [PDF]

, 2009
Clarke E. Atkins, John D. Bonagura, S. Ettinger, Philip R. Fox, Sonya G. Gordon, Jens Häggström, Robert L. Hamlin, Bruce W. Keene, Virginia Luis Fuentes, Rebecca L. Stepien   +9 more
openalex   +1 more source

Guidelines on the Management of Valvular Heart disease (Version 2012)

, 2013
A. Vahanian, Ottavio Alfieri, F. Andreotti, Manuel J. Antunes, G. Barón-Esquivias, H. Baumgartner, M. Borger, Thierry P. Carrel, M. Bonis, Arturo Evangelista, Volkmar Falk, B. Iung, Patrizio Lancellotti, L. Piérard, Susanna Price, H. Schäfers, Gerhard Schuler, Janina Stepinska, K. Swedberg, Johanna J M Takkenberg, U. Oppell, Stephan Windecker, J. Zamorano, Marian Zembala, J. Bax, Claudio Ceconi, V. Dean, Christi Deaton, R. Fagard, C. Funck-Brentano, D. Hasdai, Arno W. Hoes, Paulus Kirchhof, J. Knuuti, Philippe Kolh, Theresa A McDonagh, Cyril Moulin, B. Popescu, Željko Reiner, U. Sechtem, P. Sirnes, M. Tendera, A. Torbicki, L. Segesser, L. Badano, M. Bunc, Marc J. Claeys, Nikša Drinković, G. Filippatos, Gilbert Habib, A. Kappetein, Roland Kassab, Gregory Y. H. Lip, N. Moat, G. Nickenig, Catherine M. Otto, John Pepper, Nicolo Piazza, P. Pieper, R. Rosenhek, N. Shuka, E. Schwammenthal, J. Schwitter, P. T. Mas, P. Trindade, Thomas Walther   +65 more
semanticscholar   +1 more source

Gut microbiota‐related modulation of immune mechanisms in post‐infarction remodelling and heart failure

ESC Heart Failure, Volume 12, Issue 2, Page 942-954, April 2025.
Abstract The immune system has long been recognized as a key driver in the progression of heart failure (HF). However, clinical trials targeting immune effectors have consistently failed to improve patient outcome across different HF aetiologies. The activation of the immune system in HF is complex, involving a broad network of pro‐inflammatory and ...
Johann Roessler, Friederike Zimmermann, Bettina Heidecker, Ulf Landmesser, Arash Haghikia   +4 more
wiley   +1 more source

The use of multimodality imaging in infective endocarditis diagnosis

Cardiology Journal
Michał Wrzosek, Karina Zatorska, Anna Konopka, Małgorzata Pastuszek-Tyc, Paweł Litwiński, Piotr Trochimiuk, Tomasz Hryniewiecki, Ilona Michałowska   +7 more
doaj   +1 more source