Results 91 to 100 of about 18,080,110 (353)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Contribution of Ultrasound Strain Elastography to the Differentiation of Benign and Malignant Thyroid Lesions: Randomized Controlled Study

Van Tıp Dergisi, 2018
INTRODUCTION: We aimed to investigate the contribution of strain elastosonography to the differentiation of benign and malignant thyroid nodules.
Harun Arslan, Zülküf Akdemir, Alpaslan Yavuz, Necat İslamoglu, Mesut Özgökçe, Hüseyin Akdeniz, Abdussamet Batur, Nazım Bozan, Sebahattin Çelik, Ali Mahir Gündüz   +9 more
doaj   +1 more source

Navigating new norms: a systematic review of factors for the development of effective digital tools in higher education

FEBS Open Bio, EarlyView.
What factors make for an effective digital learning tool in Higher Education? This systematic review identifies elements of a digital tool that published examples reveal to be features of an engaging and impactful digital tool. A systematic literature search yielded 25 research papers for analysis.
Akmal Arzeman, Jessica Haines, Connie Pritchard, Stephen Rutherford, Nigel Francis   +4 more
wiley   +1 more source

A research project on interpersonal characteristics and neurotic symptoms: science or magic? [PDF]

, 2006
Deze lezing presenteert een aantal bevindingen van mijn doctoraatsonderzoek naar het verband tussen interpersoonlijke karakteristieken en neurotische symptomen.
Desmet, Mattias
core   +1 more source

From van der Corput to modern constructions of sequences for quasi-Monte Carlo rules

, 2015
In 1935 J.G. van der Corput introduced a sequence which has excellent uniform distribution properties modulo 1. This sequence is based on a very simple digital construction scheme with respect to the binary digit expansion.
Faure, Henri, Kritzer, Peter, Pillichshammer, Friedrich   +2 more
core   +3 more sources

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Philosophical Criticism of Genealogical Claims and Stoic Depoliticization of Politics: Greco-Roman Strategies in Paul's Allegorical Interpretation of Hagar and Sarah (Gal 4:21-31) [PDF]

, 2010
George H. van Kooten, “Philosophical Criticism of Genealogical Claims and Stoic Depoliticization of Politics: Greco-Roman Strategies in Paul’s Allegorical Interpretation of Hagar and Sarah (Gal 4:21-31),” in Abraham, the Nations, and the Hagarites ...
Kooten, George H. van,
core   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Life‐Threatening Bradycardia in Anti‐NMDA‐Receptor Encephalitis and a Novel Use for Permanent Pacing

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Pediatric anti‐NMDA receptor encephalitis (pNMDARE) is an autoantibody‐mediated disorder that can cause severe autonomic dysfunction, including symptomatic bradycardia and asystole. Dysautonomia can last for years, making it very challenging to manage.
Sarah Tucker, Abhijit Das, Andres Jimenez, Areeba Basit, Yike Jiang, Emily A. Smitherman, Heather Van Mater, Taylor Howard, Alexander J. Sandweiss, Kristen S. Fisher   +9 more
wiley   +1 more source

Tuz Stresi Koşullarında Yetiştirilen Soya Fasulyesi (Glycine max L.)’ nde Mikoriza Uygulamalarinin Bazı Biyokimyasal Özellikler Üzerine Etkisi

ISPEC Journal of Agricultural Sciences
Bu çalışma, soya fasulyesinde (Glycine max  L.)) tuz stresi (kontrol, 50, 100, 150, 200 mM) altında mikoriza uygulamalarının (AMF) bazı biyokimyasal değişiklikler üzerine etkilerini belirlemek amacıyla yürütülmüştür.
Erol ORAL, Rüveyde TUNÇTÜRK, Murat TUNÇTÜRK, Lütfi NOHUTÇU, Ezelhan ŞELEM   +4 more
doaj   +1 more source