Results 91 to 100 of about 129,844 (334)

Observations of Time-Domain Structures in the Plasmaspheric Plume by Van Allen Probes

Magnetochemistry, 2023
Time-domain structures (TDS), manifested as ≥ 1 ms pulses with significant parallel electric fields, play an important role in accelerating electrons in the field-aligned direction. These precipitated electrons contribute to the formation of aurora.
Shangchun Teng, Huayue Chen, Qiang Zhang, Desheng Han   +3 more
doaj   +1 more source

Oxygen ion dynamics in the Earth's ring current: Van Allen probes observations [PDF]

, 2019
Oxygen (O+) enhancements in the inner magnetosphere are often observed during geomagnetically active times, such as geomagnetic storms. In this study, we quantitatively examine the difference in ring current dynamics with and without a substantial O+ ion
Bortnik, Jacob, Gerrard, Andrew J., Gkioulidou, Matina, Li, Wen, Lyons, Larry, Ma, Qianli, Mitchell, Donald G., Reeves, Geoffrey D., Spense, Harlan E., Thorne, Richard M., Wang, Chih-Ping, Yue, Chao   +11 more
core   +1 more source

A Survey of EMIC Waves in Van Allen Probe Data

Journal of Geophysical Research: Space Physics
AbstractUsing an automated novel approach we conduct a reproducible systematic survey of electromagnetic ion cyclotron wave activity detected by Van Allen Probe B during the time period 2013 January 1–2019 July 15. We identify approximately 500 hr of EMIC wave activity, an occurrence rate of ∼ 0.85%.
Andrew Inglis, Kyle Robert Murphy, Alexa J. Halford   +2 more
openaire   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

The Evolving Space Weather System—Van Allen Probes Contribution

Space Weather, 2014
AbstractThe overarching goal and purpose of the study of space weather is clear—to understand and address the issues caused by solar disturbances on humans and technological systems. Space weather has evolved in the past few decades from a collection of concerned agencies and researchers to a critical function of the National Weather Service of NOAA ...
L. J. Zanetti, B. H. Mauk, N. J. Fox, R. J. Barnes, M. Weiss, T. S. Sotirelis, N.‐E. Raouafi, R. L. Kessel, H. N. Becker   +8 more
openaire   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Nonstorm time dynamics of electron radiation belts observed by the Van Allen Probes [PDF]

, 2014
Storm time electron radiation belt dynamics have been widely investigated for many years. Here we present a rarely reported nonstorm time event of electron radiation belt evolution observed by the Van Allen Probes during 21-24 February 2013.
Albert, Baker, Baker, Blake, Blake, Brautigam, C. A. Kletzing, Carpenter, Chao Shen, Chen, D. N. Baker, Elkington, Fuliang Xiao, G. B. Hospodarsky, G. D. Reeves, Green, H. E. Spence, H. O. Funsten, Horne, Horne, Horne, Horne, Hudson, Hui Zhu, Huinan Zheng, J. B. Blake, Kletzing, Li, Li, Mauk, Meredith, Min Zhang, Ni, Park, Reeves, Reeves, Reeves, Shprits, Shprits, Shui Wang, Spence, Su, Su, Summers, Summers, Summers, Thorne, Thorne, Thorne, Thorne, W. S. Kurth, Xiao, Yuming Wang, Zhaoguo He, Zhenpeng Su, Zong   +55 more
core   +3 more sources

TREX1, a predator for treating MSI‐H tumors?

Molecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya, Joséphine Deneft, Marc Van den Eynde   +2 more
wiley   +1 more source

Energetic, relativistic and ultra-relativistic electrons: Comparison of long-term VERB code simulations with Van Allen Probes measurements [PDF]

, 2015
In this study, we compare long-term simulations performed by the Versatile Electron Radiation Belt (VERB) code with observations from the Magnetic Electron Ion Spectrometer and Relativistic Electron-Proton Telescope instruments on the Van Allen Probes ...
Agapitov, Albert, Artemyev, Artemyev, Baker, Baker, Blake, Boyd, Brautigam, Carpenter, Cattell, Cully, Denton, Denton, Glauert, Green, Horne, Kennel, Kim, Kim, Kim, Kim, Li, Li, Mauk, Millan, O'Brien, O'Brien, Orlova, Reeves, Reeves, Reeves, Roederer, Rothwell, Russell, Schulz, Shprits, Shprits, Shprits, Shprits, Shprits, Shprits, Shprits, Shprits, Spence, Stratton, Su, Subbotin, Subbotin, Subbotin, Summers, Thorne, Thorne, Thorne, Tsyganenko, Tu, Tu, Tu, Turner, Ukhorskiy, Usanova, Vampola, Van Allen, Vernov   +63 more
core   +3 more sources

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source