Results 111 to 120 of about 357,993 (360)

Short‐term actions of epigalocatechin‐3‐gallate in the liver: a mechanistic insight into hypoglycemic and potential toxic effects

FEBS Open Bio, EarlyView.
Epigallocatechin‐3‐gallate (EGCG) acutely inhibited gluconeogenesis and enhanced glycolysis, glycogenolysis, and fatty acid oxidation in perfused rat livers. Mechanistic assays revealed mitochondrial uncoupling, inhibition of pyruvate carboxylation and glucose‐6‐phosphatase, shift of NADH/NAD+ ratios toward oxidation, and loss of membrane integrity ...
Carla Indianara Bonetti, Bruna Lopes Correia, Francielle Cristina Nakamura Manicardi, Nairana Mithieli de Queiroz Eskuarek Melo, Vanesa de Oliveira Pateis, Jurandir Fernando Comar, Anacharis Babeto de Sá‐Nakanishi, Adelar Bracht, Lívia Bracht   +8 more
wiley   +1 more source

Shock-induced prompt relativistic electron acceleration in the inner magnetosphere [PDF]

, 2015
We present twin Van Allen Probes spacecraft observations of the effects of a solar wind shock impacting the magnetosphere on 8 October 2013. The event provides details both of the accelerating electric fields associated with the shock and the response of
Baker, D. N., Boyd, A. J., Erickson, P. J., Foster, J. C., Hudson, M. K., Spence, Harlan E., Wygant, J. R.   +6 more
core   +3 more sources

Structural and functional analysis of Bacillus sarcosine oxidase and its activity toward cyclic imino acids

FEBS Open Bio, EarlyView.
Sarcosine oxidase from Bacillus sp. (SoxB) recognizes l‐proline (l‐Pro), d‐proline (d‐Pro), and l‐thioproline (l‐Tpr) as minor substrates. In this study, we measured their absorption spectra, determined the crystal structures of their enzyme complexes, and performed site‐directed mutagenesis of key residues.
Yuqi Zhang, Yoshitaka Nakajima, Masae Kurobe, Tsutomu Nakamura, Tomoki Himiyama, Yoshiaki Nishiya   +5 more
wiley   +1 more source

Interplay between RNA‐protein interactions and RNA structures in gene regulation

FEBS Open Bio, EarlyView.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko, Mauro Scaravilli, Minna‐Liisa Änkö   +2 more
wiley   +1 more source

Nonstorm time dynamics of electron radiation belts observed by the Van Allen Probes [PDF]

, 2014
Storm time electron radiation belt dynamics have been widely investigated for many years. Here we present a rarely reported nonstorm time event of electron radiation belt evolution observed by the Van Allen Probes during 21-24 February 2013.
Albert, Baker, Baker, Blake, Blake, Brautigam, C. A. Kletzing, Carpenter, Chao Shen, Chen, D. N. Baker, Elkington, Fuliang Xiao, G. B. Hospodarsky, G. D. Reeves, Green, H. E. Spence, H. O. Funsten, Horne, Horne, Horne, Horne, Hudson, Hui Zhu, Huinan Zheng, J. B. Blake, Kletzing, Li, Li, Mauk, Meredith, Min Zhang, Ni, Park, Reeves, Reeves, Reeves, Shprits, Shprits, Shui Wang, Spence, Su, Su, Summers, Summers, Summers, Thorne, Thorne, Thorne, Thorne, W. S. Kurth, Xiao, Yuming Wang, Zhaoguo He, Zhenpeng Su, Zong   +55 more
core   +3 more sources

Quasiperiodic Emissions: Fine Structure Corresponding to a Bouncing Wave

Geophysical Research Letters
Quasiperiodic (QP) emissions are whistler‐mode electromagnetic waves observed in the Earth's inner magnetosphere whose intensity has a nearly periodic time modulation with typical modulation periods on the order of minutes. Some events exhibit, on top of
F. Němec, O. Santolík, G. B. Hospodarsky, W. S. Kurth   +3 more
doaj   +1 more source

Chorus Wave Properties From Van Allen Probes: Quantifying the Impact of the Sheath Corrected Electric Field

Geophysical Research Letters, 2023
A sheath impedance model has recently been developed to describe how the variable coupling impedance between the Van Allen Probes instrumentation and the ambient plasma affects both the amplitude and phase of electric field wave measurements.
D. P. Hartley, I. W. Christopher, C. A. Kletzing, W. S. Kurth, O. Santolik, I. Kolmasova, M. R. Argall, N. Ahmadi   +7 more
doaj   +1 more source

Cytokine, Chemokine, and Neurofilament Light Chain Signatures in LGI1 Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives To investigate the value of cytokine, chemokine, and neurofilament light chain (NfL) concentrations in predicting relapse risk, chronic epilepsy, and functional impairment in LGI1 autoimmune encephalitis (AE). Methods Cytokines/chemokines (IL‐1‐beta, IL‐2, IL‐4, IL‐5, IL‐6, IL‐8/CXCL8, IL‐10, IL‐12p70, IL‐13, IL‐17A, GM‐CSF, TNF ...
Albert Aboseif, Georgios Mangioris, Binxia Yang, Vanessa K. Pazdernik, Jeffrey W. Britton, Divyanshu Dubey, Eoin P. Flanagan, Sarosh R. Irani, Gregory S. Day, Charles L. Howe, A. Sebastian López‐Chiriboga, Andrew McKeon, John R. Mills, Yahel Segal, Michel Toledano, Ivana Vodopivec, Sean J. Pittock, Anastasia Zekeridou   +17 more
wiley   +1 more source

Cross Correlation Between Plasmaspheric Hiss Waves and Enhanced Radiation Levels at Aviation Altitudes

Space Weather
Enhanced radiation in the Earth's atmosphere can pose serious hazards to pilots, aircraft passengers, and commercial space travelers. Recent results have shown, statistically, that there is a strong correlation between dose rates observed by Automated ...
Homayon Aryan, Jacob Bortnik, W. Kent Tobiska, Piyush Mehta, Rashmi Siddalingappa, Benjamin Hogan   +5 more
doaj   +1 more source

Long‐Term Evaluation of Givinostat in Duchenne Muscular Dystrophy, and Natural History Comparisons

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives This ongoing, open‐label extension study is evaluating the long‐term safety, tolerability, and efficacy of givinostat, a Class I and II histone deacetylase inhibitor, in patients with Duchenne muscular dystrophy (DMD). Methods The recruited patients completed one of two prior clinical studies (one Phase 2 and one Phase 3 [EPIDYS ...
Craig M. McDonald, Michela Guglieri, Dragana Vučinić, Gyula Acsadi, John F. Brandsema, Claudio Bruno, Erika L. Finanger, Amy Harper, Mercedes Lopez Lobato, Riccardo Masson, Nuria Muelas, Francina Munell, Yoram Nevo, Yann Péréon, Han Phan, Valeria A. Sansone, Mariacristina Scoto, Tracey Willis, Richard S. Finkel, Krista Vandenborne, Sara Cazzaniga, Silvia Montrasio, Federica Alessi, Paolo Bettica, Eugenio Mercuri, for the Givinostat Study 51 Investigators, the Cooperative International Neuromuscular Research Group (CINRG) Duchenne Natural History Study (DNHS) Investigators, the ImagingDMD Investigators, Enrico Bertini, Giacomo Pietro Comi, Eugenio Maria Mercuri, Giuseppe Vita, Sonia Messina, Claudio Bruno, Riccardo Masson, Valeria Sansone, Nathalie Goemans, Liesbeth De Waele, Laurent Servais, Teresa Gidaro, Odile Boespflug‐Tanguy, Yann Péréon, Jessika Johannsen, Astrid Blaschek, Ulrike Schara‐Schmidt, Erik Niks, Imelda de Groot, Saskia Houwen‐van Opstal, Andres Nascimento, Juan Jesus Vilchez, Nuria Muelas, Francina Munell, Marcos Madruga Garrido, Mercedes Lopez Lobato, Michaela Guglieri, Tracey Willis, Stefan Spinty, Daniel Hawcutt, Mariacristina Scoto, Jean K. Mah, Laura McAdam, Kathryn Selby, Katherine Mathews, Craig McDonald, Craig Zaidman, Barry Byrne, John Brandsema, Gyula Acsadi, Chamindra Laverty, Amy Harper, Erika Finanger, Han Phan, Yoram Nevo, Vedrana Milic Rasic, Dragana Vucinic   +74 more
wiley   +1 more source