Results 51 to 60 of about 98,361 (266)

Estimation of multi-period VaR based on the simulation and parametric methods [PDF]

تحقیقات مالی, 2016
: With regard to the Basel Committee’s emphasis on the necessity of using 10-day Value-at-Risk (VaR) internal models in order to determine minimum market risk capital requirements, and downsides of the square-root-of-time rule, our purpose is to produce ...
Mahsa Gorji, Rasoul Sajjad
doaj   +1 more source

Time Toxicity in Wilms Tumor: Quantifying the Burden of Healthcare Interaction in the First Year After Diagnosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Wilms tumor (WT) treatment imposes a significant time burden on patients and their families. Time toxicity is a patient‐centered metric that quantifies the burden of healthcare interaction. We sought to define time toxicity in the first year after diagnosis of WT and hypothesized that it would increase as tumor stage and treatment ...
Caleb Q. Ashbrook, Veerain Gupta, Nicholas J. Clark, Vijay Rings, Lauren E. Corona, Douglass B. Clayton, Daniel J. Benedetti   +6 more
wiley   +1 more source

Heterogeneity in the Global Practice of Central Nervous System Staging in Pediatric Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) involvement in childhood acute lymphoblastic leukemia (ALL) is assessed by cell counting and cytomorphology from cerebrospinal fluid (CSF) and is used for treatment stratification worldwide. The ratio of “CNS2” patients in clinical trials ranges from 3% to 40%, with unclear prognostic significance ...
Laura Almási, Bernadett Borbála Huszti, Gábor Barna, Marko Kavcic, Janez Jazbec, Lennart Lenk, Vera Münch, Sophia Polychronopoulou, Ágnes Márk, Maria Thastrup, Lüder H. Meyer, Kjeld Schmiegelow, Cornelia Eckert, Christina Halsey, Dániel J. Erdélyi   +14 more
wiley   +1 more source

Emapalumab for Immune Effector Cell‐Associated Hemophagocytic Lymphohistiocytosis‐Like Syndrome Following CD19‐Directed CAR‐T in Two Patients With B‐ALL: Clinical and Biomarker Correlates

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Immune effector cell‐associated hemophagocytic lymphohistiocytosis‐like syndrome (IEC‐HS) is a life‐threatening hyperinflammatory toxicity distinct from cytokine release syndrome (CRS) and neurotoxicity following chimeric antigen receptor T‐cell (CAR‐T) therapy. In a single‐institution retrospective cohort of pediatric and young adult patients
Thomas J. Galletta, Jeremy D. Rubinstein, Christopher E. Dandoy, Ruby Khoury, Angela Faulhaber, Christine L. Phillips, Christa Krupski   +6 more
wiley   +1 more source

The role of distribution and volatility specification in value at risk estimation: Evidence from the Johannesburg Stock Exchange

Journal of Economic and Financial Sciences, 2012
Given the volatile nature of global financial markets, managing as well as predicting financial risk plays an increasingly important role in banking and finance. The Value at Risk (VaR) measure has emerged as the most prominent measure of downside market
John M. Mwamba, Kruger Pretorius
doaj   +1 more source

Measuring the Accuracy of Forecasting Using Integrated VAR models [PDF]

Maǧallaẗ Al-Buḥūṯ Al-Mālīyyaẗ wa Al-Tiğāriyyaẗ, 2017
This study addressed the problem of prediction integration. Different weighting methods are applied to different VAR models. Some economic time series such as unemployment rates, economic growth rates and the general government expenditure series are ...
Niveen Ali Mohammed Elmor
doaj   +1 more source

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source

Short- and long-term weekly patient-reported outcomes prediction undergoing radiotherapy: single-patient time series model vs. transformer-based multi-patient time series model

BioData Mining
Background Patient-reported outcomes (PROs) are direct reports from patients on health status, symptoms, quality of life, or treatment satisfaction, offering critical insights into subjective experiences that clinical metrics may overlook.
Yang Yan, Zhong Chen, Xinglei Shen, Ronald C. Chen, Hao Gao   +4 more
doaj   +1 more source

Hierarchical Vector Auto-Regressive Models and Their Applications to Multi-subject Effective Connectivity

Frontiers in Computational Neuroscience, 2013
Vector auto-regressive (VAR) models typically form the basis for constructing directed graphical models for investigating connectivity in a brain network with brain regions of interest (ROIs) as nodes.
Cristina eGorrostieta, Mark eFiecas, Hernando eOmbao, Erin eBurke, Steven eCramer   +4 more
doaj   +1 more source

Four-dimensional ensemble variational (4D-En-Var) data assimilation for the HIgh Resolution Limited Area Model (HIRLAM) [PDF]

Nonlinear Processes in Geophysics, 2014
A four-dimensional ensemble variational (4D-En-Var) data assimilation has been developed for a limited area model. The integration of tangent linear and adjoint models, as applied in standard 4D-Var, is replaced with the use of an ensemble of non-linear ...
N. Gustafsson, J. Bojarova
doaj   +1 more source