Results 11 to 20 of about 177 (73)

Vardenafil Dihydrochloride [PDF]

Profiles of Drug Substances, Excipients and Related Methodology, 2014
Vardenafil (VAR) is synthetic, highly selective, and potent inhibitor of phosphodiesterase-5 which competitively inhibits cyclic guanosine monophosphate (cGMP) hydrolysis and thus increases cGMP levels. It is clinically approved for treatment of erectile dysfunction in men, including diabetic and postprostatectomy patients.
Abdelkader E Ashour, A F M Motiur Rahman
exaly   +4 more sources

Hyperglycemia and Endothelial Dysfunction in Atherosclerosis: Lessons from Type 1 Diabetes

International Journal of Vascular Medicine, Volume 2012, Issue 1, 2012., 2012
A clear relationship between diabetes and cardiovascular disease has been established for decades. Despite this, the mechanisms by which diabetes contributes to plaque formation remain in question. Some of this confusion derives from studies in type 2 diabetics where multiple components of metabolic syndrome show proatherosclerotic effects independent ...
Steven Daniel Funk, Arif Yurdagul Jr, A. Wayne Orr, Matthew R. Spite   +3 more
wiley   +1 more source

No Causal Link between Phosphodiesterase Type 5 Inhibition and Melanoma

The World Journal of Men's Health, 2019
USAPurpose: To examine the association between phosphodiesterase type 5 (PDE5) inhibitor use and melanoma by 1) conducting a systematic review of observational studies; and 2) determining if low PDE5A gene expression in human melanoma correlated with ...
Jenny Z. Wang, Stephanie Le, Claire Alexanian, Sucharita Boddu, Alexander Merleev, Alina Marusina, Emanual Maverakis   +6 more
doaj   +1 more source

Changes in Left Ventricular Ejection Fraction and Oxidative Stress after Phosphodiesterase Type-5 Inhibitor Treatment in an Experimental Model of Retrograde Rat Perfusion. [PDF]

Medicina (Kaunas), 2023
Krivokapic M, Alisultanovich Omarov I, Zivkovic V, Nikolic Turnic T, Jakovljevic V.   +4 more
europepmc   +1 more source

Phosphodiesterase 5 (PDE-5) inhibitors (sildenafil, tadalafil, and vardenafil) effects on esophageal motility: a systematic review. [PDF]

BMC Gastroenterol, 2023
Shafiee A, Bahri RA, Teymouri Athar MM, Afsharrezaei F, Gholami M.   +4 more
europepmc   +1 more source

Intracellular cGMP increase is not involved in thyroid cancer cell death. [PDF]

PLoS One, 2023
Alessandro S, Paradiso E, Lazzaretti C, Sperduti S, Perri C, Antoniani F, Righi S, Simoni M, Brigante G, Casarini L.   +9 more
europepmc   +1 more source

Rare vardenafil-associated Stevens-Johnson syndrome: toxic epidermal necrolysis. [PDF]

BMJ Case Rep, 2022
Grafanaki K, Lygeros S, Vryzaki EM, Georgiou S.   +3 more
europepmc   +1 more source

Neuromodulatory effect of vardenafil on aluminium chloride/D-galactose induced Alzheimer's disease in rats: emphasis on amyloid-beta, p-tau, PI3K/Akt/p53 pathway, endoplasmic reticulum stress, and cellular senescence. [PDF]

Inflammopharmacology, 2023
Awad HH, Desouky MA, Zidan A, Bassem M, Qasem A, Farouk M, AlDeab H, Fouad M, Hany C, Basem N, Nader R, Alkalleny A, Reda V, George MY.   +13 more
europepmc   +1 more source

Screening and Determination of Synthetic PDE-5 Inhibitors in Adulterated Sexual Enhancement Supplements. [PDF]

Molecules, 2022
Jairoun AA, Al-Hemyari SS, Shahwan M, Zyoud SH, Ibrahim B, Zyoud SH.   +5 more
europepmc   +1 more source

Review of Applications of Cyclodextrins as Taste-Masking Excipients for Pharmaceutical Purposes. [PDF]

Molecules, 2023
Adamkiewicz L, Szeleszczuk Ł.
europepmc   +1 more source