Results 1 to 10 of about 19,938 (290)

The Antiviral Activity of Varenicline against Dengue Virus Replication during the Post-Entry Stage

Biomedicines, 2023
Dengue virus (DENV) poses a significant global health challenge, with millions of cases each year. Developing effective antiviral drugs against DENV remains a major hurdle. Varenicline is a medication used to aid smoking cessation, with anti-inflammatory
Ching-Lin Lin, Yan-Tung Kiu, Ju-Ying Kan, Yu-Jen Chang, Ping-Yi Hung, Chih-Hao Lu, Wen-Ling Lin, Yow-Wen Hsieh, Jung-Yie Kao, Nien-Jen Hu, Cheng-Wen Lin   +10 more
doaj   +2 more sources

Varenicline Prevents LPS-Induced Inflammatory Response via Nicotinic Acetylcholine Receptors in RAW 264.7 Macrophages

Frontiers in Molecular Biosciences, 2021
The cholinergic anti-inflammatory pathway plays an important role in controlling inflammation. This study investigated the effects of varenicline, an α7 nicotinic acetylcholine receptor (α7nAChR) agonist, on inflammatory cytokine levels, cell ...
Elif Baris, Elif Baris, Hande Efe, Mukaddes Gumustekin, Mualla Aylin Arici, Metiner Tosun   +5 more
doaj   +2 more sources

Exposure to varenicline protects against locomotor alteration in a MPTP mouse model of Parkinson's disease

Brazilian Journal of Medical and Biological Research, 2021
The beneficial effects of drugs that act via nicotinic acetylcholine receptors (nAChRs) on Parkinson's disease (PD) symptomatology may explain the negative correlation between cigarette smoking and risk of this neurological condition.
A. Ribeiro-Carvalho, P.H. Leal-Rocha, J. Isnardo-Fernandes, U.C. Araújo, Y. Abreu-Villaça, C.C. Filgueiras, A.C. Manhães   +6 more
doaj   +2 more sources

Varenicline and counseling for vaping cessation: a double-blind, randomized, parallel-group, placebo-controlled trial

BMC Medicine, 2023
Background Vaping cessation is virtually unexplored. The efficacy and safety of varenicline for vaping cessation has not been studied and rigorous research is required to advance best practice and outcomes for people who use electronic cigarettes (EC ...
Pasquale Caponnetto, Davide Campagna, Jasjit S. Ahluwalia, Christopher Russell, Marilena Maglia, Paolo Marco Riela, Carmelo Fabio Longo, Barbara Busa, Riccardo Polosa   +8 more
doaj   +2 more sources

Neuropsychiatric safety of varenicline in the general and COPD population with and without psychiatric disorders: a retrospective cohort study in a real-world setting

BMJ Open, 2021
Objectives To evaluate the real-world association between varenicline and neuropsychiatric adverse events (NPAEs) in general and chronic obstructive pulmonary disease (COPD) population with and without psychiatric disorders compared with nicotine ...
Yuanyuan Wang, Bob Wilffert, Eelko Hak, H. Marike Boezen, Jens H. Bos, Catharina C.M. Schuiling-Veninga, Job F. M. van Boven   +6 more
doaj   +2 more sources

Effects of varenicline on sympatho-vagal balance and cue reactivity during smoking withdrawal: a randomised placebo-controlled trial [PDF]

Tobacco Induced Diseases, 2016
Introduction Varenicline is an effective smoking cessation medication. Some concern has been raised that its use may precipitate adverse cardiovascular events although no patho-physiological mechanism potentially underlying such an effect has been ...
Helge Haarmann, Alexandra Gossler, Peter Herrmann, Slavtcho Bonev, Xuan Phuc Nguyen, Gerd Hasenfuß, Stefan Andreas, Tobias Raupach   +7 more
doaj   +3 more sources

Varenicline in the treatment of tobacco dependence

Neuropsychiatric Disease and Treatment, 2008
Karl Fagerström1, John Hughes21Smokers Information Centre, Fagerström Consulting AB, Berga Alle 1, 25452 Helsingborg, Sweden; 2University of Vermont, Burlington, Vermont, USAAbstract: Varenicline, a partial agonist of α4& ...
Karl Fagerström, John Hughes
doaj   +5 more sources

Two-year efficacy of varenicline tartrate and counselling for inpatient smoking cessation (STOP study): A randomized controlled clinical trial.

PLoS ONE, 2020
IntroductionVarenicline tartrate is superior for smoking cessation to other tobacco cessation therapies by 52 weeks, in the outpatient setting. We aimed to evaluate the long-term (104 week) efficacy following a standard course of inpatient-initiated ...
Kristin V Carson-Chahhoud, Brian J Smith, Matthew J Peters, Malcolm P Brinn, Faisal Ameer, Kuljit Singh, Robert Fitridge, Simon A Koblar, Jim Jannes, Antony J Veale, Sharon Goldsworthy, Khin Hnin, Adrian J Esterman   +12 more
doaj   +2 more sources

Use of low-dose varenicline in hospitalized smokers: A case series low-dose varenicline in hospitalized smokers [PDF]

SAGE Open Medical Case Reports
Nicotine replacement therapy is the primary medication used to treat tobacco dependence in hospitalized patients. Recent evidence shows that varenicline is more effective than nicotine replacement, but varenicline side effects limit its use in the ...
Rachael L. Joyner, Remi E. Phillips, Farid A. Manshaii, James M. Davis   +3 more
doaj   +2 more sources

Pilot safety evaluation of varenicline for the treatment of methamphetamine dependence [PDF]

Journal of Experimental Pharmacology, 2009
Todd Zorick1, Rajkumar J Sevak1, Karen Miotto1, Steven Shoptaw2,4, Aimee-Noelle Swanson2, Clayton Clement1, Richard De La Garza II1*, Thomas F Newton1*, Edythe D London1,3,41Departments of Psychiatry and Biobehavioral Sciences, 2Family Medicine ...
Todd Zorick, Rajkumar J Sevak, Karen Miotto, et al   +3 more
doaj   +2 more sources