Results 1 to 10 of about 15,118 (197)
Investigation of varenicline and tropisetron in latent inhibition and novel object recognition in mice [PDF]
Scientific ReportsThere is currently no treatment for cognitive-impairment associated with schizophrenia (CIAS). Animal and human studies suggest that nicotinic cholinergic agonists and 5-HT3 antagonists have potential therapeutic benefits.
Lorena R. Lizarraga-Valderrama +5 more
doaj +2 more sources
Comparative Effectiveness of Cytisinicline and Varenicline for Smoking Cessation: A Matching-Adjusted Indirect Comparison (MAIC) [PDF]
Journal of Health Economics and Outcomes Research# Background Pharmacologic options for supporting smoking cessation remain limited. Cytisinicline is a plant-based alkaloid that selectively binds to α4β2 nicotinic acetylcholine receptors, reducing nicotine craving and withdrawal symptoms, and has ...
Mark Rubinstein +3 more
doaj +2 more sources
Effects of varenicline on sympatho-vagal balance and cue reactivity during smoking withdrawal: a randomised placebo-controlled trial [PDF]
Tobacco Induced Diseases, 2016 BACKGROUND: Varenicline is an effective smoking cessation medication. Some concern has been raised that its use may precipitate adverse cardiovascular events although no patho-physiological mechanism potentially underlying such an effect has been ...
Andreas, S +7 more
core +3 more sources
Missing Data Sensitivity Analyses for Alcohol Research [PDF]
Alcohol, Clinical and Experimental Research, Volume 50, Issue 5, May 2026.This paper presents that missing data are a pervasive challenge in alcohol research, where nonresponse is often plausibly related to unobserved drinking—so‐called missing not at random (MNAR) processes. This paper presents a practical, step‐by‐step framework for conducting MNAR sensitivity analyses using shared parameter and selection models ...
Craig K. Enders, Lara A. Ray
wiley +2 more sources
Utilization of varenicline among Kansas Medicaid enrollees. [PDF]
PLoS ONEBackgroundSmoking prevalence among Medicaid beneficiaries is twice that of privately insured adults, yet effective smoking cessation treatments remain underutilized.
Nathalia M Machado +3 more
doaj +2 more sources
Pilot Safety Evaluation of Varenicline for the Treatment of Methamphetamine Dependence. [PDF]
Journal of Experimental Pharmacology, 2009 Despite the worldwide extent of methamphetamine dependence, no medication has been shown to effectively treat afflicted individuals. One relatively unexplored approach is modulation of cholinergic system function.
Clement, Clayton +8 more
core +2 more sources
Brazilian Journal of Medical and Biological Research, 2021 The beneficial effects of drugs that act via nicotinic acetylcholine receptors (nAChRs) on Parkinson's disease (PD) symptomatology may explain the negative correlation between cigarette smoking and risk of this neurological condition.
A. Ribeiro-Carvalho +6 more
doaj +1 more source
The Antiviral Activity of Varenicline against Dengue Virus Replication during the Post-Entry Stage
Biomedicines, 2023 Dengue virus (DENV) poses a significant global health challenge, with millions of cases each year. Developing effective antiviral drugs against DENV remains a major hurdle. Varenicline is a medication used to aid smoking cessation, with anti-inflammatory
Ching-Lin Lin +10 more
doaj +1 more source
Journal of Pharmacological Sciences, 2020 Varenicline is a widely used and effective drug for smoking cessation. We previously reported that varenicline aggravates atherosclerosis in apolipoprotein E knockout (ApoE KO) mice.
Mitsuhisa Koga +7 more
doaj +1 more source
Indian Journal of Psychiatry, 2023 According to the Global Burden of Disease (GBD) Study conducted in 2019, smoking tobacco leads to over 8 million deaths each year. Hence, it is crucial to identify optimal smoking cessation therapy. To compare the efficacy of varenicline versus bupropion
Ashish R. Patel +2 more
doaj +1 more source