Results 21 to 30 of about 19,420 (250)

Effect of Cytisine vs Varenicline on Smoking Cessation: A Randomized Clinical Trial.

Journal of the American Medical Association (JAMA), 2021
Importance Cytisine is more effective than placebo and nicotine replacement therapy for smoking cessation. However, cytisine has not been tested against the most effective smoking cessation medication, varenicline, which is associated with adverse events
R. Courtney, H. McRobbie, P. Tutka, Natasha Weaver, D. Petrie, C. Mendelsohn, A. Shakeshaft, Saki Talukder, Christel Macdonald, D. Thomas, Benjamin Kwan, Natalie Walker, C. Gartner, R. Mattick, C. Paul, S. G. Ferguson, N. Zwar, R. Richmond, C. Doran, Veronica C. Boland, W. Hall, R. West, M. Farrell   +22 more
semanticscholar   +1 more source

Effect of Combination Treatment With Varenicline and Nicotine Patch on Smoking Cessation Among Smokers Who Drink Heavily

JAMA Network Open, 2022
Key Points Question Is the combination of varenicline tartrate and nicotine patch a more effective treatment than placebo with nicotine patch for smoking cessation in adult cigarette smokers who drink heavily?
Andrea King, Ashley Vena, H. de Wit, J. Grant, Dingcai Cao   +4 more
semanticscholar   +1 more source

E-cigarettes to Augment Stop Smoking In-person Support and Treatment With Varenicline (E-ASSIST): A Pragmatic Randomized Controlled Trial

Nicotine & Tobacco Research, 2022
Aim To examine whether, in adults receiving behavioral support, offering e-cigarettes together with varenicline helps more people stop smoking cigarettes than varenicline alone. Methods A two-group, parallel arm, pragmatic randomized controlled trial was
Harry Tattan-Birch, L. Kock, Jamie Brown, E. Beard, L. Bauld, R. West, L. Shahab   +6 more
semanticscholar   +1 more source

Efficacy and Safety of Varenicline for Smoking Cessation in Patients With Type 2 Diabetes

JAMA Network Open, 2022
This randomized clinical trial examines the effect of smoking cessation medication and counseling in smokers with type 2 diabetes.
C. Russo, Magdalena Walicka, P. Caponnetto, F. Cibella, Marilena Maglia, A. Alamo, D. Campagna, L. Frittitta, Maurizio Di Mauro, G. Caci, A. Krysiński, E. Franek, R. Polosa   +12 more
semanticscholar   +1 more source

Effect of Varenicline Added to Counseling on Smoking Cessation Among African American Daily Smokers: The Kick It at Swope IV Randomized Clinical Trial.

Journal of the American Medical Association (JAMA), 2022
Importance African American smokers have among the highest rates of tobacco-attributable morbidity and mortality in the US, and effective treatment is needed for all smoking levels.
L. Cox, Nicole L. Nollen, M. Mayo, B. Faseru, A. Greiner, E. Ellerbeck, R. Krebill, R. Tyndale, N. Benowitz, J. Ahluwalia   +9 more
semanticscholar   +1 more source

Cytisine versus varenicline for smoking cessation in New Zealand indigenous Māori: a randomized controlled trial

Addiction, 2021
Aim To determine whether cytisine was at least as effective as varenicline in supporting smoking abstinence for ≥ 6 months in New Zealand indigenous Māori or whānau (extended‐family) of Māori, given the high smoking prevalence in this population.
Natalie Walker, Barry Smith, J. Barnes, Marjolein E. A. Verbiest, V. Parag, S. Pokhrel, Mary-Kaye Wharakura, Tina Lees, Huber Cubillos Gutierrez, B. Jones, C. Bullen   +10 more
semanticscholar   +1 more source

Evaluating Treatment Mechanisms of Varenicline: Mediation by Affect and Craving.

Nicotine & Tobacco Research, 2022
INTRODUCTION Negative reinforcement models posit that relapse to cigarette smoking is driven in part by changes in affect and craving during the quit attempt.
S. Tonkin, C. Colder, M. Mahoney, G. Swan, P. Cinciripini, R. Schnoll, T. George, R. Tyndale, Larry W Hawk   +8 more
semanticscholar   +1 more source

Semi-PBPK Modeling and Simulation to Evaluate the Local and Systemic Pharmacokinetics of OC-01(Varenicline) Nasal Spray

Frontiers in Pharmacology, 2022
This study aimed to build a nasal semi-physiologically based pharmacokinetic (PBPK) model to predict the intranasal pharmacokinetic (PK) of the OC-01(varenicline) nasal spray and accelerate the development of this drug.
Xiaofei Wu, Fan Zhang, Mengyang Yu, Faming Ding, Jinghui Luo, Bo Liu, Yuan Li, Zhiping Li, Hongyun Wang   +8 more
semanticscholar   +1 more source

Varenicline: For smoking cessation

Kathmandu University Medical Journal, 1970
Varenicline, a partial agonist of α4β2 nicotinic acetylcholine receptor (nAChR), is the most recently approved drug for smoking cessation. Despite the availability of effective treatments for smoking cessation, such as nicotine replacement therapy and Bupropion sustained-release, abstinence rates remain less than optimal.
Pinakini K. Shankar, J. Rao
openaire   +4 more sources

Efficacy of Combining Varenicline and Naltrexone for Smoking Cessation and Drinking Reduction: A Randomized Clinical Trial.

American Journal of Psychiatry, 2021
OBJECTIVE Pharmacological treatments that can concomitantly address cigarette smoking and heavy drinking stand to improve health care delivery for these highly prevalent co-occurring conditions.
L. Ray, ReJoyce Green, Craig K. Enders, A. Leventhal, E. Grodin, Gang Li, Aaron C. Lim, E. Hartwell, A. Venegas, Lindsay R Meredith, Steven J. Nieto, S. Shoptaw, Diana Ho, K. Miotto   +13 more
semanticscholar   +1 more source