Frontiers in Molecular Biosciences, 2021 The cholinergic anti-inflammatory pathway plays an important role in controlling inflammation. This study investigated the effects of varenicline, an α7 nicotinic acetylcholine receptor (α7nAChR) agonist, on inflammatory cytokine levels, cell ...
E. Baris +4 more
semanticscholar +1 more source
The effectiveness, safety and cost-effectiveness of cytisine versus varenicline for smoking cessation in an Australian population: a study protocol for a randomized controlled non-inferiority trial [PDF]
, 2019 Smoking cessation medications are effective but often underutilised because of costs and side effects. Cytisine is a plant-based smoking cessation medication with over 50 years of use in Central and Eastern Europe.
Boland, Veronica C. +19 more
core +1 more source
Addiction, 2021 Background and Aims Analysed using classical frequentist hypothesis testing with alpha set to 0.05, the Evaluating Adverse Events in a Global Smoking Cessation Study (EAGLES) did not find enough evidence to reject the hypothesis of no difference in ...
E. Beard +10 more
semanticscholar +1 more source
Alcohol use disorder severity moderates clinical response to varenicline.
Alcoholism: Clinical and Experimental Research, 2021 BACKGROUND In a multisite clinical trial, varenicline was effective in reducing drinking in both smoking- and nonsmoking patients with alcohol dependence.
S. Donato, ReJoyce Green, L. Ray
semanticscholar +1 more source
Low Dopamine D2/D3 Receptor Availability is Associated with Steep Discounting of Delayed Rewards in Methamphetamine Dependence. [PDF]
, 2015 BackgroundIndividuals with substance use disorders typically exhibit a predilection toward instant gratification with apparent disregard for the future consequences of their actions.
Ballard, Michael E +7 more
core +3 more sources
Effects of varenicline on sympatho-vagal balance and cue reactivity during smoking withdrawal: a randomised placebo-controlled trial [PDF]
, 2016 BACKGROUND: Varenicline is an effective smoking cessation medication. Some concern has been raised that its use may precipitate adverse cardiovascular events although no patho-physiological mechanism potentially underlying such an effect has been ...
Andreas, S +7 more
core +1 more source
Varenicline: cardiovascular safety [PDF]
Canadian Medical Association Journal, 2011 Serious methodologic issues limit the reliability and relevance of the results of the analysis by Singh and colleagues, in which they reported an “increased risk of serious adverse cardiovascular events” associated with varenicline based on a meta-analysis of 14 studies.[1][1] First ...
openaire +3 more sources
Varenicline decreases nicotine but not alcohol self-administration in genetically selected Marchigian Sardinian alcohol-preferring (msP) rats [PDF]
, 2015 Background: Alcohol and nicotine are largely co-abused. Here, we investigated whether concurrent exposure to both addictive drugs influences each other's consumption and whether varenicline attenuates alcohol consumption in the presence of nicotine ...
Ciccocioppo, Roberto +4 more
core +1 more source
Efficacy of Electronic Cigarettes vs Varenicline and Nicotine Chewing Gum as an Aid to Stop Smoking
JAMA Internal MedicineImportance Electronic cigarettes (ECs) are often used by smokers as an aid to stopping smoking, but evidence is limited regarding their efficacy compared with nicotine replacement therapy (NRT), and no evidence is available on how their efficacy compares
Hao-Xiang Lin +11 more
semanticscholar +1 more source
The Food and Drug Administration and varenicline:should Risk Communication Be Improved? [PDF]
, 2016 [no ...
Davies, Neil M, Thomas, Kyla H
core +1 more source