Results 191 to 200 of about 3,116,070 (323)
Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry
Molecular Oncology, EarlyView.Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder +11 morewiley +1 more sourceMET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer
Molecular Oncology, EarlyView.Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song +11 morewiley +1 more sourceVariability in the analysis of a single neuroimaging dataset by many teams
Nature, 2019 Rotem Botvinik-Nezer, Felix Holzmeister, Colin Camerer, Anna Dreber, J. Huber, M. Johannesson, Michael Kirchler, Roni Iwanir, J. Mumford, Alison Adcock, P. Avesani, Blazej M. Baczkowski, Aahana Bajracharya, Leah Bakst, Sheryl Ball, Marco Barilari, N. Bault, D. Beaton, J. Beitner, R. Benoit, R. Berkers, J. Bhanji, B. Biswal, Sebastian Bobadilla-Suarez, T. Bortolini, Katherine L. Bottenhorn, Alexander Bowring, S. Braem, Hayley R. Brooks, Emily G. Brudner, C. Calderon, J. Camilleri, Jaime J. Castrellon, L. Cecchetti, E. Cieslik, Z. Cole, O. Collignon, R. Cox, William A. Cunningham, Stefan Czoschke, Kamalaker Dadi, Charles P. Davis, A. de Luca, M. Delgado, L. Demetriou, Jeffrey B. Dennison, X. Di, E. Dickie, Ekaterina Dobryakova, Claire Donnat, J. Dukart, Niall W. Duncan, Joke Durnez, A. Eed, S. Eickhoff, Andrew Erhart, Laura Fontanesi, G. M. Fricke, A. Galván, Remi Gau, S. Genon, T. Glatard, E. Glerean, J. Goeman, S. Golowin, Carlos González-García, Krzysztof J. Gorgolewski, Cheryl Grady, Mikella A. Green, João F. Guassi Moreira, Olivia Guest, S. Hakimi, J. P. Hamilton, R. Hancock, G. Handjaras, Bronson B. Harry, Colin Hawco, P. Herholz, Gabrielle Herman, Stephan Heunis, F. Hoffstaedter, J. Hogeveen, S. Holmes, Chuan-Peng Hu, S. Huettel, M. Hughes, V. Iacovella, Alexandru D. Iordan, P. Isager, A. I. Isik, Andrew Jahn, Matthew R. Johnson, T. Johnstone, Michael J. E. Joseph, A. Juliano, J. Kable, Michalis Kassinopoulos, Cemal Koba, Xiang-zhen Kong, T. Koscik, N. Kucukboyaci, Brice A. Kuhl, Sebastian Kupek, A. Laird, C. Lamm, R. Langner, Nina Lauharatanahirun, Hongmi Lee, Sangil Lee, A. Leemans, Andrea Leo, E. Lesage, Flora Li, Monica Li, P. C. Lim, Evan N. Lintz, Schuyler W. Liphardt, A. L. Losecaat Vermeer, Bradley C. Love, Michael L. Mack, Norberto Malpica, Theo F. Marins, Camille Maumet, Kelsey R. McDonald, Joseph T. McGuire, Helena Melero, A. M. Méndez Leal, B. Meyer, Kristin N. Meyer, P. Mihai, G. Mitsis, J. Moll, D. Nielson, G. Nilsonne, Michael P. Notter, E. Olivetti, Adrian I. Onicas, P. Papale, K. Patil, J. Peelle, A. Pérez, D. Pischedda, J. Poline, Yanina Prystauka, Shruti Ray, P. Reuter-Lorenz, R. Reynolds, E. Ricciardi, J. Rieck, Anais Rodriguez-Thompson, Anthony Romyn, T. Salo, G. Samanez-Larkin, Emilio Sanz-Morales, M. Schlichting, D. Schultz, Qiang Shen, M. Sheridan, Fu Shiguang, J. Silvers, Kenny Skagerlund, Alec Smith, D. Smith, Peter Sokol-Hessner, Simon Richard Steinkamp, Sarah M. Tashjian, B. Thirion, J. Thorp, G. Tinghög, Loreen Tisdall, S. Tompson, Claudio Toro-Serey, J. Torre, L. Tozzi, V. Truong, L. Turella, Anna E. van’t Veer, Tom Verguts, J. Vettel, Sagana Vijayarajah, Khoi Vo, M. Wall, W. Weeda, S. Weis, David J. White, David Wisniewski, Alba Xifra-Porxas, Emily Yearling, Sangsuk Yoon, R. Yuan, K. Yuen, Lei Zhang, Xu Zhang, Joshua Zosky, Thomas E. Nichols, R. Poldrack, T. Schonberg +196 moresemanticscholar +1 more sourceChemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation
Molecular Oncology, EarlyView.This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam +14 morewiley +1 more source
