Results 101 to 110 of about 2,254,450 (359)

Asymptotically optimal multistage tests of simple hypotheses

open access: yes, 2007
A family of variable stage size multistage tests of simple hypotheses is described, based on efficient multistage sampling procedures. Using a loss function that is a linear combination of sampling costs and error probabilities, these tests are shown to ...
Bartroff, Jay
core   +1 more source

Accountable Care Organizations and Transaction Cost Economics [PDF]

open access: yes, 2016
Using a Transaction Cost Economics (TCE) approach, this paper explores which organizational forms Accountable Care Organizations (ACOs) may take. A critical question about form is the amount of vertical integration that an ACO may have, a topic central ...
Mick, Stephen S. Farnsworth   +1 more
core   +2 more sources

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

Cost Analysis and Waste Elimination in Efforts to Prepare Inpatient Room Rates as an Efficiency and Effectiveness Strategy in Managing a Hospital Business

open access: yesMedical Technology and Public Health Journal
ABC Hospital is a class B hospital with an increase in capacity to 238 beds. The process of cost analysis and unit cost preparation is very necessary in determining the burden of each service unit.
Budhi Setianto   +2 more
doaj   +1 more source

International environmental agreements, uncertainty and learning: the case of stock dependent unit damage costs [PDF]

open access: yes
In Ulph (2002) I analysed how the possibility of future resolution of uncertainty about damage costs affected the incentives and timing for countries to join a self-enforcing international environmental agreement (IEA).
Ulph, Alistair
core  

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

open access: yesFEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake   +4 more
wiley   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

open access: yesFEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

open access: yesFEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo   +7 more
wiley   +1 more source

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