Results 111 to 120 of about 295,908 (279)

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Fréchet Envelopes of Nonlocally Convex Variable Exponent Hörmander Spaces

Abstract and Applied Analysis, 2016
We show that the dual Bp·locΩ′ of the variable exponent Hörmander space Bp(·)loc(Ω) is isomorphic to the Hörmander space B∞c(Ω) (when the exponent p(·) satisfies the conditions ...
Joaquín Motos, María Jesús Planells, César F. Talavera   +2 more
doaj   +1 more source

Variable exponent perturbation of a parabolic equation with $p(x)$-Laplacian

Electronic Journal of Qualitative Theory of Differential Equations, 2019
This paper is concerned with the study of the global existence and the decay of solutions of an evolution problem driven by an anisotropic operator and a nonlinear perturbation, both of them having a variable exponent. Because the nonlinear perturbation
Aldo Trajano Lourêdo, Manuel Milla Miranda, Marcondes Rodrigues Clark   +2 more
doaj   +1 more source

A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento, Daniela F. Santos, Tuane C. R. G. Vieira, Tiago F. Outeiro   +3 more
wiley   +1 more source

Holder continuity with exponent (1+alpha)/2 in the time variable for solutions of parabolic equations

Electronic Journal of Differential Equations, 2015
We consider the regularity of solutions for some parabolic equations. We show Holder continuity with exponent $(1+\alpha )/2$, with respect to the time variable, when the gradient in the space variable of the solution has the Holder continuity with ...
Junichi Aramaki
doaj  

Long‐Term Efficacy of Immunotherapy in Autoimmune Autonomic Ganglionopathy—A 10‐Year Follow Up Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autoimmune autonomic ganglionopathy (AAG) is a rare but potentially treatable cause of severe autonomic failure. Evidence guiding long‐term immunotherapy, treatment sequencing, and residual autonomic impairment is limited. We evaluated long‐term treatment response, residual autonomic dysfunction, and relapse patterns in patients with
Giacomo Chiaro, Shiwen Koay, Gordon T. Ingle, Patricia McNamara, Laura Watson, Fion Bremner, Valeria Iodice   +6 more
wiley   +1 more source

Sex‐Stratified Association of Regional Dopamine Transporter Binding With Disease Progression in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To clarify the clinical relevance of dopamine transporter single‐photon emission computed tomography (DAT‐SPECT) abnormalities in amyotrophic lateral sclerosis (ALS), with a prespecified focus on sex‐stratified associations with disease progression and short‐term prognosis.
Tomoya Kawazoe, Keizo Sugaya, Kentaro Hayashi, Keiko Hino, Yasuhiro Nakata, Kota Bokuda, Toshio Shimizu, Kazushi Takahashi   +7 more
wiley   +1 more source

Real interpolation with variable exponent

Le Matematiche, 2017
We present the real interpolation with variable exponent and we prove the basic properties in analogy to the classical real interpolation. More precisely, we prove that under some additional conditions, this method can be reduced to the case of fixed exponent.
openaire   +2 more sources

A Qualitative Analysis of Patient Perspectives and Preferences in Lupus Management to Guide Lupus Guidelines Development

Arthritis Care &Research, EarlyView.
Objective A patient‐centered approach for chronic disease management, including systemic lupus erythematosus (SLE), aligns treatment with patients’ values and preferences, leading to improved outcomes. This paper summarizes how patient experiences, perspectives, and priorities informed the American College of Rheumatology (ACR) 2024 Lupus Nephritis (LN)
Shivani Garg, Izzy Hartel, Lisa R. Sammaritano, Anca Askanase, Bonnie L. Bermas, Maria Dall'Era, Alí Duarte‐García, Victoria P. Werth, Brad Rovin, Reem A. Mustafa, Amy S. Turner, Bené Williams, Brian L. Ung, Hiya Bhavsar, Monique C. Gore‐Massy, Nahirannette Pulido, Natacha Guerrero, Natalie M. Smith, Wambui Machua, Linda T. Hiraki, Mary Beth Son   +20 more
wiley   +1 more source

Emden-Fowler problem for discrete operators with variable exponent

Electronic Journal of Differential Equations, 2014
In this article, we prove the existence of homoclinic solutions for a p(.)-Laplacian difference equation on the set of integers, involving a coercive weight function and a reaction term satisfying the Ambrosetti-Rabinowitz condition.
Maria Malin
doaj