Results 61 to 70 of about 296,333 (284)
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
The concentration-compactness principle for variable exponent spaces and applications [PDF]
, 2009 In this paper we extend the well-known concentration -- compactness principle of P.L. Lions to the variable exponent case.
Bonder, J. Fernandez, Silva, A.
core +3 more sources
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Differential inclusion obstacle problems with variable exponents and convection terms [PDF]
, 2022 Bin Ge, Patrizia Pucci
openalex +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Hölder Quasicontinuity in Variable Exponent Sobolev Spaces
Journal of Inequalities and Applications, 2007 We show that a function in the variable exponent Sobolev spaces coincides with a Hölder continuous Sobolev function outside a small exceptional set.
Kinnunen Juha +2 more
doaj
Interplay between RNA‐protein interactions and RNA structures in gene regulation
FEBS Open Bio, EarlyView.Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko +2 more
wiley +1 more source
Existence of solutions for a variable exponent system without PS conditions
Electronic Journal of Differential Equations, 2015 In this article, we study the existence of solution for the following elliptic system of variable exponents with perturbation terms $$\displaylines{ -\hbox{div}| \nabla u| ^{p(x)-2}\nabla u)+|u| ^{p(x)-2}u =\lambda a(x)| u| ^{\gamma(x)-2}u+F_{u}(x,u ...
Li Yin +3 more
doaj
Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays
FEBS Open Bio, EarlyView.We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul +3 more
wiley +1 more source