Results 41 to 50 of about 132,957 (262)
The Variable Geometry in Supersonic Compressors [PDF]
ASME 1977 International Gas Turbine Conference and Products Show, 1977 A flexible inlet guide vane has been designed for an independent control of the pre- or counter-swirl condition over the blade height. This model has then been investigated with a Mach 2 supersonic rotor and proved to produce large variations of the design mass flow and pressure ratio with 6 percent loss in efficiency for the preswirl conditions.
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Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Impact of variable geometry miniflaps on sailplane flight characteristics
Aviation, 2017 Miniflaps (also known as mini-TED, active Gurnay flaps, etc.) located at the wing trailing edge enable to increase wing lift and reduce the aerodynamic drag.
Peep Lauk +2 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Confinement of Vibrations in Variable-Geometry Nonlinear Flexible Beam
Shock and Vibration, 2014 In this paper, we propose a novel strategy for controlling a flexible nonlinear beam with the confinement of vibrations. We focus principally on design issues related to the passive control of the beam by proper selection of its geometrical and physical ...
W. Gafsi +3 more
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Optimal Rotor Design of Synchronous Reluctance Machines Considering the Effect of Current Angle
Mathematics, 2021 The torque density and efficiency of synchronous reluctance machines (SynRMs) are greatly affected by the geometry of the rotor. Hence, an optimal design of the SynRM rotor geometry is highly recommended to achieve optimal performance (i.e., torque ...
Hegazy Rezk +3 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
The geometry of proper quaternion random variables
Signal Processing, 2017 Second order circularity, also called properness, for complex random variables is a well known and studied concept. In the case of quaternion random variables, some extensions have been proposed, leading to applications in quaternion signal processing (detection, filtering, estimation). Just like in the complex case, circularity for a quaternion-valued
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FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source