Results 111 to 120 of about 3,727,733 (308)

Unraveling Similarities and Differences Between Non-Negative Garrote and Adaptive Lasso: A Simulation Study in Low- and High-Dimensional Data

Stats
Penalized regression methods are widely used for variable selection. Non-negative garrote (NNG) was one of the earliest methods to combine variable selection with shrinkage of regression coefficients, followed by lasso.
Edwin Kipruto, Willi Sauerbrei
doaj   +1 more source

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

FEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

A Bayesian Framework that integrates heterogeneous data for inferring gene regulatory networks

Frontiers in Bioengineering and Biotechnology, 2014
Reconstruction of gene regulatory networks (GRNs) from experimental data is a fundamental challenge in systems biology. A number of computational approaches have been developed to infer GRNs from mRNA expression profiles.
Tapesh eSantra
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Pre-Processing Ensemble Modeling Based on Faster Covariate Selection Calibration for Near-Infrared Spectroscopy

Applied Sciences
Ensemble techniques are crucial for preprocessing near-infrared (NIR) data, yet effectively integrating information from multiple preprocessing methods remains challenging.
Yonghong Wu, Yukun Zhou, Xiaojing Chen, Zhonghao Xie, Shujat Ali, Guangzao Huang, Leiming Yuan, Wen Shi, Xin Wang, Lechao Zhang   +9 more
doaj   +1 more source

Variable selection for inferential models with relatively high-dimensional data: Between method heterogeneity and covariate stability as adjuncts to robust selection [PDF]

, 2020
Eliana Lima, Peers Davies, Jasmeet Kaler, Fiona Lovatt, Martin Green   +4 more
openalex   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Rapid and Accurate Measurement of Major Soybean Components Using Near-Infrared Spectroscopy

Agronomy
This study addresses the urgent need for the rapid, non-destructive assessment of key soybean components, including moisture, fat, and protein, using near-infrared (NIR) spectroscopy.
Chenxiao Li, Jiatong Yu, Sheng Wang, Qinglong Zhao, Qian Song, Yanlei Xu   +5 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source