Results 91 to 100 of about 2,137,948 (299)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Critical Speed Control for a Fixed Blade Variable Speed Wind Turbine
Energies, 2017 A critical speed controller for avoiding a certain rotational speed is presented. The controller is useful for variable speed wind turbines with a natural frequency in the operating range.
Morgan Rossander +2 more
doaj +1 more source
Variable geometry manned orbital vehicle Patent [PDF]
, 1970 Variable geometry manned orbital vehicle having high aerodynamic efficiency over wide speed range and incorporating auxiliary pivotal ...
Henry, B. Z., Jr., Spencer, B., Jr.
core +1 more source
General conditions for scale-invariant perturbations in an expanding universe
, 2011 We investigate the general properties of expanding cosmological models which generate scale-invariant curvature perturbations in the presence of a variable speed of sound.
A. Linde +10 more
core +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Gas turbine engine fuel control [PDF]
, 1973 A variable orifice system is described that is responsive to compressor inlet pressure and temperature, compressor discharge pressure and rotational speed of a gas-turbine engine.
Gold, H. S.
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Characteristics of variable speed limit systems
European Transport Research Review, 2018 The control algorithm used for deciding on the speed limit in variable speed limit systems is crucial for the performance of the systems. The algorithm is designed to fulfil the purpose of the variable speed limit system, which can be one or several of ...
Ellen F. Grumert +2 more
doaj +1 more source
A numerical study of a variable-density low-speed turbulent mixing layer
, 2017 Direct numerical simulations of a temporally-developing, low-speed, variable-density, turbulent, plane mixing layer are performed. The Navier-Stokes equations in the low-Mach number approximation are solved using a novel algorithm based on an extended ...
Almagro, Antonio +2 more
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source