Results 61 to 70 of about 336,215 (315)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Direct Flux Field Oriented Control of IPM Drives with Variable DC-Link in the Field-Weakening Region [PDF]

, 2009
This paper presents the direct flux control of an interior permanent-magnet (IPM) motor drive in the field-weakening region. The output torque is regulated by the coordinated control of the stator flux amplitude and the current component in quadrature ...
Armando, Eric Giacomo, Guglielmi, Paolo, Pellegrino, Gian-Mario Luigi   +2 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Tuning of modern speed drives using IFOC: A case study for a five-phase induction machine

Results in Engineering
Electric machines have existed since the beginning of the 19th century. Although variable-speed drive technology has evolved considerably during the last years, the indirect field-oriented control technique has been in use as a standard control method ...
F. Barrero, M.G. Satué, F. Colodro, M.R. Arahal   +3 more
doaj   +1 more source

Speed-Control of Energy Regulation Based Variable-Speed Electrohydraulic Drive

Strojniški vestnik – Journal of Mechanical Engineering, 2013
The variable-speed electrohydraulic drive is a promising drive principle due to its high energy efficiency and large speed-range. However, its slow response and poor low-speed behaviour limit its application. To address these disadvantages, a energy regulation based variable-speed electrohydraulic drive is proposed.
Chen, Guojin, Jin, Bo, Ni, Jing, Xu, Ming   +3 more
openaire   +2 more sources

Observer-based Fault Detection and Diagnosis for Mechanical Transmission Systems with Sensorless Variable Speed Drives [PDF]

, 2015
Observer based approaches are commonly embedded in sensorless variable speed drives for the purpose of speed control. It estimates system variables to produce errors or residual signals in conjunction with corresponding measurements. The residual signals
Abusaad, Samieh, Ball, Andrew, Gu, Fengshou, Zhang, R.   +3 more
core  

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source