Results 71 to 80 of about 349,224 (309)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Model predictive control of a free piston compressor/expander with an integrated linear motor/alternator [PDF]

, 2019
Linear positive displacement machines are becoming increasingly more attractive for applications that are normally known as unconquerable niches of rotary and scroll machines.
De Paepe, Michel, Gusev, Sergei, Ziviani, Davide   +2 more
core   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Saliency Ratio and Power Factor of IPM Motors Optimally Designed for High Efficiency and Low Cost Objectives [PDF]

, 2016
This paper uses formal mathematical optimization techniques based on parametric finite-element-based computationally efficient models and differential evolution algorithms.
Demerdash, Nabeel, Ionel, Dan M., Zhang, Peng   +2 more
core   +1 more source

High-performance control of dual-inertia servo-drive systems using low-cost integrated SAW torque transducers [PDF]

, 2006
—This paper provides a systematic comparative study of compensation schemes for the coordinated motion control of two-inertia mechanical systems. Specifically, classical proportional–integral (PI), proportional–integral–derivative (PID), and resonance ...
Bingham, Chris, OSullivan, T M, Schofield, N   +2 more
core   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Online optimal flux-weakening control of permanent-magnet brushless AC drives [PDF]

, 2000
An enhanced online optimal control strategy, which maximizes the flux-weakening performance of a brushless AC motor, is described, and applied to motors having different rotor topologies: interior (radial or circumferential), inset, and surface-mounted ...
Chen, Y.S., Howe, D., Zhu, Z.Q.
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Detection and Diagnostics of Bearing and Gear Fault under Variable Speed and Load Conditions Using Heterogeneous Signals

Energies
In industrial applications, rotating machines operate under real-time variable speed and load regimes. In the presence of faults, the degradation of critical components is accelerated significantly.
Mahfoud Bouzouidja, Moncef Soualhi, Abdenour Soualhi, Hubert Razik   +3 more
doaj   +1 more source

Comparison of Induction and PM Synchronous motor drives for EV application including design examples [PDF]

, 2012
Three different motor drives for electric traction are compared, in terms of output power and efficiency at the same stack dimensions and inverter size. Induction motor (IM), surface-mounted permanent-magnet (PM) (SPM), and interior PM (IPM) synchronous ...
Boazzo, Barbara, Guglielmi, Paolo, Pellegrino, Gian-Mario Luigi, Vagati, Alfredo   +3 more
core   +1 more source