Results 141 to 150 of about 5,204,122 (311)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

AUTOMATED VARIABLE STAR CLASSIFICATION USING THE NORTHERN SKY VARIABILITY SURVEY [PDF]

, 2009
D. I. Hoffman, T. E. Harrison, B. J. McNamara   +2 more
openalex   +1 more source

Identification of Orbital Eclipses in LAMOST J024048.51+195226.9, a Candidate AE Aqr-type Cataclysmic Variable Star [PDF]

, 2020
Colin Littlefield, P. Garnavich
openalex   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

More Old Dogs, More New Tricks: Photographic Plates of the Globular Cluster M10 (NGC 6254) Digitized with a Commercial Scanner

The Astronomical Journal
Photographic plates of the globular cluster M10 (NGC 6254) that were recorded at the Dominion Astrophysical Observatory between 1931 and 1934 have been digitized with a commercial scanner.
T. J. Davidge
doaj   +1 more source

Variable Star Research by the PLANET Collaboration [PDF]

, 2000
Michael D. Albrow, K. R. Pollard, Jean‐Philippe Beaulieu, J. Caldwell, J. W. Menzies, P. Vermaak, D. L. DePoy, B. S. Gaudi, A. Gould, Richard W. Pogge, M. Dominik, R. M. Naber, P. D. Sackett, J. Greenhill, K. Hill, Stephen R. Kane, R. Watson, R. Martin, A. Williams, K. C. Sahu   +19 more
openalex   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Discovery of 79 δ Scuti Stars in NGC 3532 Suggests a Decrease of Pulsator Occurrence with Age

The Astrophysical Journal
Many A–F type stars do not display δ Scuti pulsations, despite being located within the instability strip. Open clusters provide a unique opportunity to study δ Scuti pulsations among coeval populations with uniform chemical composition. Here we use data
Ian Berry, Daniel Huber, Yaguang Li, Daniel Hey, Timothy R. Bedding, Simon J. Murphy   +5 more
doaj   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source