Results 141 to 150 of about 136,231 (311)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
A New Variable Star in Delphinus
, 2005 Bu çalışma; Glinos, Wallach-Levy ve Levy'nin Delphinus'daki yeni bir değişen yıldız ile ilgili son çalışmasında da gösterildiği gibi, bir değişen yıldızın keşif işlemlerini ortaya koymaktadır.This brief paper highlights the discovery of a new ...
Waagen, Elizabeth +3 more
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Observations of Variable Stars [PDF]
Publications of the Astronomical Society of the Pacific, 1896 openaire +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
The variability of the Be stars
, 1970 Using the photometric and Be-star catalogues existing at La Plata, the photometric behavior of a sample of 140 Be stars has been studied over an average time interval of eleven years. As compared with a control sample of 100 normal B stars, about 50 % of the Be stars show variations in V and about 30 %, in B-V and U-B. These results confirm Feinstein’s
Ferrer, L., Jaschek, Carlos
openaire +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
The Astrophysical JournalNew results on the behavior of the double-mode RR Lyrae V338 Boo are presented. The Transiting Exoplanet Survey Satellite (TESS) observed this star again in 2022, and an observing campaign of the American Association of Variable Star Observers (AAVSO ...
Kenneth Carrell +15 more
doaj +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source