Results 1 to 10 of about 340,530 (320)

An R- and I-Band Photometric Variability Survey of the Cygnus OB2 Association

open access: yes, 2010
We present a catalog of photometrically variable stars discovered within two 21'.3 X 21'.3 fields centered on the Cygnus OB2 association. There have hitherto been no deep optical variability studies of Cyg OB2 despite it being replete with early-type ...
Abdo   +39 more
core   +1 more source

Circulating histones as clinical biomarkers in critically ill conditions

open access: yesFEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez   +17 more
wiley   +1 more source

An Investigation into the Variability of Luminous Blue Variable Stars with TESS

open access: yesThe Astronomical Journal
Luminous blue variables (LBVs) are enigmatic, evolved, massive stars. Their variability has been observed to be episodic with large eruptions, along with variations on timescales of days to decades.
Becca Spejcher   +5 more
doaj   +1 more source

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

open access: yesFEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao   +7 more
wiley   +1 more source

Intron‐oriented HTLV‐1 integration in an adult T‐cell leukemia/lymphoma cell line sustains expression of intact ift81 mRNA

open access: yesFEBS Letters, EarlyView.
In the adult T‐cell leukemia/lymphoma (ATL) cell line ED, the human T‐cell leukemia virus type 1 (HTLV‐1) provirus was integrated into the intron of the ift81 gene in the antisense orientation. Despite this integration, both the intact ift81 and the viral oncogene hbz were simultaneously expressed, likely due to the functional insufficiency of viral ...
Mayuko Yagi   +5 more
wiley   +1 more source

TESS Light Curves of Cataclysmic Variables. V. Improved or Corrected Orbital Periods of 53 Systems

open access: yesThe Astronomical Journal
The long and continuous high-time-resolution coverage of many stars by the Kepler and TESS space missions permit to explore periodic phenomena with a much higher precision than is possible with terrestrial observations.
Albert Bruch
doaj   +1 more source

Cyclic nucleotide signaling as a drug target in retinitis pigmentosa

open access: yesFEBS Letters, EarlyView.
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää   +2 more
wiley   +1 more source

TRAF2 binds to TIFA via a novel motif and contributes to its autophagic degradation

open access: yesFEBS Letters, EarlyView.
TRAF family members couple receptor signalling complexes to downstream outputs, but how they interact with these complexes is not always clear. Here, we show that during ADP‐heptose signalling, TRAF2 binding to TIFA requires two short sequence motifs in the C‐terminal tail of TIFA, which are distinct from the TRAF6 binding motif.
Tom Snelling   +4 more
wiley   +1 more source

Stellar Variability toward the Galactic Open Cluster NGC 7209

open access: yesThe Astrophysical Journal
We present the analysis of stellar variability in an open cluster NGC 7209 using optical V -band CCD photometric observations. Out of 4499 stars in our study, we detected 284 candidate variables, including one identified previously.
Dorothy M. Mwanzia   +10 more
doaj   +1 more source

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