Results 141 to 150 of about 51,534 (310)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Observational Properties of β Cephei Stars: 88 New Samples Discovered Based on TESS and Gaia Data

open access: yesThe Astrophysical Journal Supplement Series
We present a systematic investigation of β Cephei (BCEP) stars by integrating photometric data from the Transiting Exoplanet Survey Satellite (TESS) with astrometric parameters from Gaia Data Release 3.
Xiang-dong Shi   +7 more
doaj   +1 more source

Variable stars across the observational hr diagramm

open access: yes, 2008
An overview of pulsating variable stars across the observational Hertzprung-Russel (HR) diagram is presented, together with a summary of their global properties. The HR diagram is presented with a third colour-coded dimension, visualizing the fraction of
Laurent Eyer, Nami Mowlavi
core  

The variability of the Be stars

open access: yes, 1970
Using the photometric and Be-star catalogues existing at La Plata, the photometric behavior of a sample of 140 Be stars has been studied over an average time interval of eleven years. As compared with a control sample of 100 normal B stars, about 50 % of the Be stars show variations in V and about 30 %, in B-V and U-B. These results confirm Feinstein’s
Ferrer, L., Jaschek, Carlos
openaire   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Stellar Variability and Distance Indicators in the Near-infrared in Nearby Galaxies. II. Pulsating Stars in the Carina Dwarf Spheroidal

open access: yesThe Astronomical Journal
We present homogeneous, near-infrared ( JHK _s bands) time-series observations of the classical Carina dwarf spheroidal (dSph) galaxy to determine accurate and precise distances using the pulsating stars as standard candles.
Chow-Choong Ngeow   +3 more
doaj   +1 more source

Understanding variable stars

open access: yes, 2007
A concise introduction and overview of variable stars, for undergraduate students and experienced amateur astronomers, first published in ...
Percy, John R
core  

Evolution of Variable Stars [PDF]

open access: yes, 1986
Throughout the domain of the H R diagram lie groupings of stars whose luminosity varies with time. These variable stars can be classified based on their observed properties into distinct types such as ..beta.. Cephei stars, delta Cephei stars, and Miras,
Becker, S. A.
core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

Review on Photometric Study of Variable Stars

open access: yes
This literature review focuses on variable stars, which exhibit changes in brightness over time. This topic is vital in astronomical research, particularly due to the abundance of telescope data available in archives.
Aathil, Abdullah Mohamed
core   +1 more source

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