Results 211 to 220 of about 2,526,596 (235)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Primary Care Cost Sharing in Medicare Advantage.

JAMA Health Forum
Jiang C, Lu CA, He L, Hong AS, Hu X, Mullins M, Jiao B, Liao JM.   +7 more
europepmc   +1 more source

Bureaucracy, happiness, and satisfaction at work. [PDF]

PLoS One
Tu J, Hill SJ.
europepmc   +1 more source

New variable stars in the globular cluster NGC 5694

, 2012
Catelan, Márcio, Andrade, Lara Rodrigues de   +1 more
core  

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Decoding spatial transcriptomics across multicellular and subcellular resolutions. [PDF]

Nat Commun
Zhao C, Liu T, Miller LM, Li H, Zhao H, Barnett D, Yuan R, Zhang H, Wang Q, Eddens T, Torok KS, Zhou AX, Dai Z, Alcorn JF, Huang H, Chen W.   +15 more
europepmc   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Associations between lipid metabolism and Henoch-Schönlein purpura nephritis in children: a systematic review and meta-analysis. [PDF]

Ital J Pediatr
Zhang X, Yang Z, Guo J, Li J.
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

The C-terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity. [PDF]

FEBS Open Bio
Yadav VK, Shweta S, Malhotra M, Maurya V, Kumar A.   +4 more
europepmc   +1 more source