Results 31 to 40 of about 29,276 (167)

Cost‐utility analysis of nusinersen–risdiplam switch in patients with spinal muscular atrophy in Croatia: A discrete event simulation model

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Introduction In recent years, the treatment of spinal muscular atrophy (SMA), a rare disease, has significantly progressed, improving patients' survival and overall quality of life. However, current SMA treatments are expensive, and some (nusinersen) are very inconvenient for patients.
Andrej Belančić   +4 more
wiley   +1 more source

The evolving therapeutic landscape of spinal muscular atrophy – A scoping review of investigational agents, emerging delivery technologies and strategic innovations

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Spinal muscular atrophy (SMA) is a severe neuromuscular disease with emerging therapeutic complexity. This review aims to systematically map the global pipeline of investigational treatments for SMA. Using ClinicalTrials.gov and complementary international registries, we identified 21 planned or ongoing interventional trials from 2020 to 2025 targeting
Andrej Belančić   +7 more
wiley   +1 more source

Adapting the Interrelated Two-way Clustering method for Quantitative Structure-Activity Relationship (QSAR) Modeling of a Diverse Set of Chemical Compounds

open access: yes, 2013
Interrelated Two-way Clustering (ITC) is an unsupervised clustering method developed to divide samples into two groups in gene expression data obtained through microarrays, selecting important genes simultaneously in the process.
Basak, Subhash C.   +2 more
core   +1 more source

The Global Epilepsy Needs Study (GENS): A mixed‐methods, multi‐country exploration of the unmet psychosocial and everyday needs of people with epilepsy

open access: yesEpilepsia Open, EarlyView.
Abstract Objective While epilepsy research has largely focused on medical management and clinical outcomes, less attention has been given to the unmet psychosocial and everyday needs of people with epilepsy (PWE), particularly in low‐ and middle‐income countries.
Gus A. Baker   +52 more
wiley   +1 more source

Consensus‐Based Safety Recommendations for Informal Home Care: A Mixed Methods Study

open access: yesResearch in Nursing &Health, EarlyView.
ABSTRACT As home‐based care expands globally, informal caregivers are responsible for medical and nursing responsibilities, raising serious concerns about safety and risk management. This study proposes expert‐informed, safety recommendations tailored to informal caregiving in home settings.
Nida Abed   +9 more
wiley   +1 more source

Present and future downslope windstorms in the Scandinavian Mountains from a kilometre‐scale climate model

open access: yesQuarterly Journal of the Royal Meteorological Society, EarlyView.
Kilometre‐scale climate simulations for Scandinavia indicate the importance of high resolution for reproducing downslope windstorms (DWs). Scandinavian DWs on average induce a limited local warming but with large variability due to the region's complex orography.
Patrik Jureša   +5 more
wiley   +1 more source

Near‐resonant excitation of the Adriatic barotropic modes: The seiche events of December 2019

open access: yesQuarterly Journal of the Royal Meteorological Society, EarlyView.
This study examines severe flooding in the northern Adriatic Sea in December 2019, which existing forecasting systems failed to predict. Analysis of wind and sea‐level data, alongside reanalysis datasets and a high‐resolution hydrodynamic model, revealed a wind‐induced resonance mechanism.
Marco Bajo   +3 more
wiley   +1 more source

Meander‐Bend Erosion Dynamics Along a Gravel‐Bed River: Insights From Short‐Term UAV Monitoring

open access: yesRiver Research and Applications, EarlyView.
ABSTRACT Riverbank erosion is a natural process in meandering rivers that contributes to sediment supply and geomorphic diversity, yet it can threaten infrastructure and human activities within the floodplain. Recently, many studies have used high‐resolution remote sensing technologies to measure bank erosion, but they often focus on technical aspects ...
Katarina Pavlek   +2 more
wiley   +1 more source

Impact Analysis of Changes in Human Resource Capital on Economic Development - from Gravely Underdeveloped to Highly Developed Societies [PDF]

open access: yes
This research encompasses 177 countries around the world with the data on human resource variables for the year 2005. The countries have been put into four groups: gravely underdeveloped, developing, developed, and highly developed.
Boris Crnkovic, Zeljko Pozega
core  

Cameras do not always take a full picture: wolf activity patterns revealed by accelerometers versus road‐positioned camera traps

open access: yesRemote Sensing in Ecology and Conservation, EarlyView.
Camera traps have become an increasingly popular non‐invasive alternative to animal‐attached devices for studying wildlife behaviour. This study compared wolf (Canis lupus) activity patterns derived from collar accelerometers and road‐positioned camera traps and revealed strong overall agreement but also important seasonal and diel mismatches between ...
Katarzyna Bojarska   +7 more
wiley   +1 more source

Home - About - Disclaimer - Privacy