Results 121 to 130 of about 12,143,956 (343)

An Example of the TIC Applied to Education: “School 2.0” in Castilla-La Mancha

open access: yesIndex Comunicación, 2014
The article looks at the partial results of a broader research integrated in a R&D project on public policies for promotion to the Information Society in Spain.
María del Mar López Talavera   +1 more
doaj  

An Investigation into Lean Implementation Preparedness in the Engineering Projects Sector

open access: yesSystems
Lean methodologies, a system widely used in the manufacturing industry, have demonstrated numerous benefits and added significant value to the industry.
Uzayr Karimulla   +2 more
doaj   +1 more source

Variability

open access: yes
At a closer look, Mundania is constantly re-created. Order is, as we have seen, merely temporarily and situationally fixed. Mundania is like an image on a computer screen that seems to be static, but beneath and beyond the glass surface of the screen there is a constant flow of energy, processes and invisible work upholding what is experienced as a ...
openaire   +1 more source

A working model for cytoplasmic assembly of H/ACA snoRNPs

open access: yesFEBS Letters, EarlyView.
Dyskerin is the component of nuclear H/ACA ribonucleoproteins (RNPs) endowed with pseudouridine synthase catalytic activity. Two isoforms of human dyskerin have been characterized: the abundant Iso1, mainly nuclear, and the shorter Iso3, mainly cytoplasmic but occasionally imported into nuclei.
Alberto Angrisani, Maria Furia
wiley   +1 more source

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

open access: yesFEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer   +10 more
wiley   +1 more source

Pulsation in Hot Main-Sequence Stars: Comparison of Observations with Models

open access: yesUniverse
The locations of hot pulsating variables in the H–R diagram are found using the effective temperatures derived from spectroscopic analysis and luminosities from Gaia parallaxes.
Luis A. Balona
doaj   +1 more source

La práctica de la arquitectura como racionalización sistémica [PDF]

open access: yesDearq, 2010
La práctica del diseño arquitectónico es de singular complejidad al involucrar gran cantidad de variables. La incomprensión de esta complejidad ha implicado la reducción del discurso general de la profesión, hasta ser concebido hoy en día como un ...
Camilo Villate, Brando Tamayo
doaj  

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

open access: yesFEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican   +7 more
wiley   +1 more source

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