Results 201 to 210 of about 12,143,956 (343)

Large language models forecast patient health trajectories enabling digital twins. [PDF]

NPJ Digit Med
Makarov N, Bordukova M, Quengdaeng P, Garger D, Rodriguez-Esteban R, Schmich F, Menden MP.   +6 more
europepmc   +1 more source

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

Light-Variation of the Spectrum Variable HD 124224.

, 1958
R. H. Hardie
openalex   +1 more source

A New Variable Star with the Shortest Known Period [PDF]

, 1952
O. J. Eggen
openalex   +1 more source

Influence of individual models and studies on quantitative mitigation findings in the IPCC Sixth Assessment Report. [PDF]

Nat Commun
Sognnaes I, Peters GP.
europepmc   +1 more source

The subcellular distribution of phosphorylated Y‐box‐binding protein‐1 at S102 in colorectal cancer patients, stratified by KRAS mutational status and clinicopathological features

Molecular Oncology, EarlyView.
This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau, Stephan Forchhammer, Birgit Fehrenbacher, Lejla Mahmutovic, Marcus Scharpf, Gunnar Blumenstock, Martin Schaller, Irina Bonzheim, Shayan Khozooei, Mahmoud Toulany   +9 more
wiley   +1 more source

Harvard College Observatory, circular no. 7. Ten new variable stars.

, 1896
E. C. Pickering
openalex   +1 more source

A machine learning framework for estimating the probability of blacklegged tick population establishment in eastern Canada using Earth observation data. [PDF]

PLoS One
Ghanbari H, Siebels K, Dumas A, Acheson ES, Bouchard C, Crandall K, Leighton PA, Ogden NH, Rees EE.   +8 more
europepmc   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

The variable velocities in the line of sight of epsilon Librae, H Draconis, lambda Andromedae, epsilon Ursae Minoris, and omega Draconis.

, 1899
W. W. Campbell
openalex   +1 more source