Results 71 to 80 of about 12,143,956 (343)
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source
Revista Habanera de Ciencias Médicas, 2008 La búsqueda de alternativas que promuevan el mejoramiento continuo de la calidad en la formación de los recursos humanos de las Ciencias de la Salud es una tarea priorizada del Ministerio de Salud Publica.
Jacinta Otero Iglesias +2 more
doaj
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Quartic Forms in Many Variables [PDF]
, 2014 We show that a quartic $p$-adic form with at least $3192$ variables possesses a non-trivial zero. We also prove new results on systems of cubic, quadratic and linear forms.
Dumke, Jan H.
core
On the interpretation of variables [PDF]
SIMULATION, 1985 Correct usage is discussed for concepts and terminology in various types of models, namely simulation, regression, and user's mental models. Therefore, a strict distinction is made between variables and parameters; also, different measurement scales are distinguished.
openaire +4 more sources
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
Studies in Communication Sciences, 2023 The Open Access Database of Variables for Content Analysis (DOCA) collects, systematizes, and evaluates operationalizations for standardized manual and automatic content analysis in the field of communication science.
Franziska Oehmer-Pedrazzi +4 more
doaj +1 more source
FEBS Letters, EarlyView.In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source
A stepwise emergence of evolution in the RNA world
FEBS Letters, EarlyView.How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley +1 more source
Index for Assessing the Performance Level of Vehicular Traffic on Urban Streets
Urban ScienceVehicular transportation is one of the most widely used modes in modern cities for reaching key destinations such as workplaces, healthcare facilities, recreational areas, and educational institutions, among others.
Ernesto De la Cruz-Nicolás +4 more
doaj +1 more source