Results 141 to 150 of about 817,120 (303)

Estimating variance components in Stata [PDF]

This article gives a brief overview of the popular methods for estimating variance components in linear models and describes several ways to obtain such estimates in Stata for various experimental designs.
Yulia Marchenko
core  

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

REHE: Fast variance components estimation for linear mixed models. [PDF]

Genet Epidemiol, 2021
Yue K, Ma J, Thornton T, Shojaie A.
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Investigating the impact of non-additive genetic effects in the estimation of variance components and genomic predictions for heat tolerance and performance traits in crossbred and purebred pig populations. [PDF]

BMC Genom Data, 2023
de Oliveira LF, Brito LF, Marques DBD, da Silva DA, Lopes PS, Dos Santos CG, Johnson JS, Veroneze R.   +7 more
europepmc   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

A link function approach to heterogeneous variance components

Genetics Selection Evolution, 1998
d'Arnoldi Caroline, Quaas Richard L, Foulley Jean-Louis   +2 more
doaj   +1 more source

Which method is optimal for estimating variance components and their variability in generalizability theory? evidence form a set of unified rules for bootstrap method. [PDF]

PLoS One, 2023
Li G.
europepmc   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Heritability and variance components of seed size in wild species: influences of breeding design and the number of genotypes tested. [PDF]

Heredity (Edinb), 2023
Larios E, Ramirez-Parada TH, Mazer SJ.
europepmc   +1 more source