Results 181 to 190 of about 2,210,403 (291)

Estimation of (co)variance components for very large datasets and complex single-step genomic models. [PDF]

Genet Sel Evol
Bermann M, Legarra A, Aguilar I, Alvarez-Munera A, Misztal I, Lourenco D.   +5 more
europepmc   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Correction: Which method is optimal for estimating variance components and their variability in generalizability theory? Evidence from a set of unified rules for bootstrap method. [PDF]

PLoS One
Li G.
europepmc   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Comparison between linear mixed model and threshold model in the estimation of variance components in age at first calving and milk production in buffaloes. [PDF]

Front Vet Sci
Camargo-Júnior RNC, de Araújo CV, Gomes MNB, Marques JRF, da Silva WC, Sousa CEL, de Andrade RL, de Oliveira AS, da Silva ÉBR, Cara JRF, Lourenço-Júnior JB, Santos AM, Silva AGME.   +12 more
europepmc   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Variance-components tests for genetic association with multiple interval-censored outcomes. [PDF]

Stat Med
Choi J, Xu Z, Sun R.
europepmc   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Equivalence of variance components between standard and recursive genetic models using LDL' transformations. [PDF]

Genet Sel Evol
Varona L, López-Carbonell D, Srihi H, Hervás-Rivero C, González-Recio Ó, Altarriba J.   +5 more
europepmc   +1 more source