Results 211 to 220 of about 8,447,173 (379)

Variance-components tests for genetic association with multiple interval-censored outcomes. [PDF]

Stat Med
Choi J, Xu Z, Sun R.
europepmc   +1 more source

Proportion Explained Component Variance in Second-Order Scales: A Note on a Latent Variable Modeling Approach [PDF]

Tenko Raykov, Christine DiStefano, Yusuf Ransome   +2 more
openalex   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Equivalence of variance components between standard and recursive genetic models using LDL' transformations. [PDF]

Genet Sel Evol
Varona L, López-Carbonell D, Srihi H, Hervás-Rivero C, González-Recio Ó, Altarriba J.   +5 more
europepmc   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Comparing the Structural Components Variance Estimator and U-Statistics Variance Estimator When Assessing the Difference Between Correlated AUCs with Finite Samples

, 2017
Anna L Bosse
openalex   +2 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Genetic variance components of the growth curve for Isfahan indigenous chicken. [PDF]

Vet Med Sci
Ghaderi-Zefrehei M, Rafeie F, Zakizadeh S, Torshizi ME, Peters SO, Smith J.   +5 more
europepmc   +1 more source

Genetic variance estimates and relationship among yield and yield components of mung bean (Vigna radiata l.)

Qudrah Olaitan Oloyede-Kamiyo, Mayowa Segun Oladipo, Paul Chiedozie Ukachukwu, Adedotun Daniel Adewumi   +3 more
openalex   +2 more sources

Variance Risk Premium Components and International Stock Return Predictability

, 2019
Juan M. Londoño, Nancy R. Xu
openalex   +1 more source