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Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Astrocyte heterogeneity in brain metastases
Molecular Oncology, EarlyView.Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver +2 more
wiley +1 more source
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Variance components for discordances
Mathematical Biosciences, 1992Tests for biotyping isolates give a result that is classified as either positive or negative, indicative of growth or nongrowth of bacteria. The reproducibility of such tests is measured by the number of discordances in replicates of the same measurement.
Z, Jiao, K M, Matawie, C A, McGilchrist
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On estimation of variance components*
Statistica Neerlandica, 1980SummaryIn this survey paper the estimation of variance components is given. The least squares approach in variance component estimation is a unifying principle which includes the analysis of variance estimators and the MINQUE. When normality is assumed the maximum likelihood estimators can be used. Many variance component estimators are not permissible
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Components of variance: a miscellany
Statistical Methods in Medical Research, 1998Some general issues connected with components of variance are reviewed. These include matters of definition, of formal inference in a normal-theory context, of goodness of fit, and of simple methods for unbalanced data.
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COMPONENTS OF VARIANCE MODELS WITH TRANSFORMATIONS
Australian Journal of Statistics, 1996SummaryPower transformations are a popular way to improve the agreement between the observations and the assumptions in a statistical model. In this paper it is assumed that the data, after appropriate power transformation Λ, satisfies a variance components model, with independent Gaussian components. The focus is on inference for quantities which have
Taylor, Jeremy M. G. +2 more
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Consistency of Estimates of Variance Components
Biometrics, 1951THE ESTIMATION OF VARIANCE COMPONENTS has important applications in genetic research, and geneticists were among the first to use analysis of variance extensively for that purpose. Early examples of component estimation in genetics are contained in papers by Lush et al. (1934), Bywaters (1937), and Stonaker and Lush (1942).
R E, COMSTOCK, H F, ROBINSON
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Nonlinear Component of Variance Models
Biometrika, 1992SUMMARY General aspects of nonlinearity in the context of component of variance models are discussed, and two special topics are examined in detail. Firstly, simple procedures, both formal and informal, are proposed for describing departures from normal-theory linear models.
Solomon, P. J., Cox, D. R.
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Variance-Importance of System Components
IEEE Transactions on Reliability, 1982The paper defines the variance-importance of a component as the product of a relative sensitivity coefficient of component variance and the variance of component-unreliability estimate. Variance-importance is useful for identifying components that appreciably contribute to the uncertainty of system unreliability.
Nakashima, Kyoichi, Yamato, Kazuharu
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