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RETRACTION: W. Pan, W. Li, J. Zhao, Z. Huang, J. Zhao, S. Chen, C. Wang, Y. Xue, F. Huang, Q. Fang, J. Wang, D. Brand, and S. G. Zheng, “lncRNA‐PDPK2P Promotes Hepatocellular Carcinoma Progression Through the PDK1/AKT/Caspase 3 Pathway,” Molecular Oncology 13, no. 10 (2019): 2246–2258, https://doi.org/10.1002/1878-0261.12553.
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Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
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TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach+8 more
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Functional Variance Processes [PDF]
We introduce the notion of a functional variance process to quantify variation in functional data. The functional data are modeled as samples of smooth random trajectories observed under additive noise. The noise is assumed to be composed of white noise and a smooth random process—the functional variance process—which gives rise to smooth random ...
Muller, Hans-Georg+2 more
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On polynomial variance functions [PDF]
Let ℱ be a natural exponential family onℝ and (V, Ω) be its variance function. Here, Ω is the mean domain of ℱ andV, defined on Ω, is the variance of ℱ. A problem of increasing interest in the literature is the following: Given an open interval Ω⊂ℝ and a functionV defined on Ω, is the pair (V, Ω) a variance function of some natural exponential family ...
Daoud Bshouty+2 more
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Variance function estimation for immunoassays
Computer Programs in Biomedicine, 1980A computer program is described which implements a recently described [1], modified likelihood method of determining an appropriate weighting function to use when fitting immunoassay dose-response curves. The relationship between the variance of the response and its mean value is assumed to have an exponential form, and the best fit to this model is ...
Gillian M. Raab+2 more
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Journal of Applied Statistics, 1990
Estimates of variance from samples depend strongly on extreme values. Incomplete variance functions may be used to explain the unreliability of variance estimates when the distribution is long-tailed.
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Estimates of variance from samples depend strongly on extreme values. Incomplete variance functions may be used to explain the unreliability of variance estimates when the distribution is long-tailed.
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A GRAPHICAL DIAGNOSTIC FOR VARIANCE FUNCTIONS
Australian & New Zealand Journal of Statistics, 2007SummaryThis paper proposes diagnostic plots for regression variance functions. It shows how to extend graphical methodology that uses Bayesian sampling for checking the regression mean function to also check the variance function. Plots can be constructed quickly and easily for any model of interest.
Iain Pardoe, R. Dennis Cook
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Variance weighting functions in radioimmunoassay calibration
American Journal of Physiology-Endocrinology and Metabolism, 1986Software packages for radioimmunoassay calibration assume that expected counting rate is a function of ligand dose. Previous studies have indicated that variances of counting rate are also related to dose, but the structure of individual assays does not permit precise estimation of counting rate variances at individual doses.
D. M. Henricks+2 more
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