Results 101 to 110 of about 869,396 (264)
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
Bayesian Estimation of Unknown Heteroscedastic Variances [PDF]
We propose a Bayesian procedure to estimate possibly heteroscedastic variances of the regression error term, without assuming any structure on them. What we propose in this paper, may be construed as a Conditional Bayesian procedure that is conditioned ...
Hiroaki Chigira, Tsunemasa Shiba
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Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Asymptotic Validity of the Bayes-Inspired Indifference Zone Procedure: The Non-Normal Known Variance Case [PDF]
, 2015 We consider the indifference-zone (IZ) formulation of the ranking and selection problem in which the goal is to choose an alternative with the largest mean with guaranteed probability, as long as the difference between this mean and the second largest ...
Frazier, Peter I. +1 more
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FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Wishart variate generators [PDF]
Subroutine WSHRT for generating matrix of variances and covariances of Wishart ...
Hocking, R. R., Smith, W. B.
core +1 more source
Revised stochastic analysis of an input-output model [PDF]
, 1992 A main difficulty of regional analysis is the inaccuracy of regional input-output data. A natural framework for investigation is stochastic input-output analysis.
Raa, Thijs ten, Steel, Mark F.J.
core +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
VAR analysis and the Great Moderation [PDF]
Most analyses of the U.S. Great Moderation have been based on structural VAR methods, and have consistently pointed towards good luck as the main explanation for the greater macroeconomic stability of recent years.
Benati, Luca, Surico, Paolo
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