Results 71 to 80 of about 256,651 (263)
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Estimating Common Mean in Heteroscedastic Variances Model
MathematicsBayes estimators for the unknown mean against a reference, non-informative prior distribution for both the mean and independent variances are derived. I entertain the scenario with two groups of observables with the same unknown mean.
Andrew L. Rukhin
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
The Misuses of Reliability Coeffient and Sampling Variance in Educational Research
Jurnal Ilmu Pendidikan, 2016 Many educational researchers report the reliability of their data. They also report tha sampling techniques used in their research. Some of the reports treat the reliability coefficients and sampling variances incorrectly.
Dali S. Naga
doaj +1 more source
The Annals of Mathematical Statistics, 1949 In this paper recent results on the lower bound to the variance of unbiased estimates have been brought together. Some of them have been extended to sequential estimates and the others have been improved to some extent. In the last section a general method for generating a system of orthogonal polynomials with respect to a certain class of weight ...
openaire +3 more sources
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
The formal demography of kinship VI: Demographic stochasticity and variance in the kinship network [PDF]
Demographic ResearchBACKGROUND: Although the matrix model for kinship networks includes many demographic processes, it is deterministic. It provides values of age-stage distributions of kin, but no information on (co)variances. Because kin populations are small, demographic
Hal Caswell
doaj +1 more source