Results 91 to 100 of about 709,139 (287)
Molecular CytogeneticsBackground Nanopore sequencing is a technology that holds great promise for identifying all types of human genome variations, particularly structural variations.
Catarina Silva +7 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
A simple data-adaptive probabilistic variant calling model [PDF]
Algorithms for Molecular Biology, 2015 19 pages, 6 ...
Steve Hoffmann +2 more
openaire +5 more sources
nikostr/dna-seq-deepvariant-glnexus-variant-calling: v0.3.1
, 2021 This release fixes some minor bugs. It bumps the Snakemake version requirement to v6.5. This is due to snakedeploy not working with singularity containers in previous versions of Snakemake.
nikostr
core +1 more source
Genomic variant calling at scale across human populations [PDF]
, 2023 In the last fifty years, our ability to sequence DNA has rapidly improved. In particular, high-throughput next-generation sequencing (NGS) technology has enabled sequencing and analysis at the scale of hundreds of thousands to millions of human genomes ...
Zarate, Samantha L
core +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Summary of variant calling following DNA sequencing.
, 2014 Summary of variant calling following DNA sequencing.
Max Käller (8703) +6 more
core +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Variant calling results on a GCAT benchmark.
, 2014 Variant calling results on a GCAT benchmark.
Bernt Popp (512553) +2 more
core +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source