Results 141 to 150 of about 4,172,585 (318)
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
De rol van codewisseling in conversaties, zowel in gesproken taal als in gesprekken op internet.
In onderzoek naar codewisseling waren conversationele aspecten lange tijd ondergeschikt aan grammaticale analyses. Werk van o.a. Auer heeft daar verandering in gebracht. In dit artikel wordt ingegaan op de manier van analyseren die Auer voorstelt in zijn
Nortier, J.M. +2 more
core
Knowledge on spatial distribution, provenance and delivery mode of surface sediment aids in interpretation of nearby sediment records for paleoenvironmental reconstruction.
Li Wu +12 more
doaj +1 more source
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Assessment of the global ocean heat content and North Atlantic heat transport over 1993–2020
Understanding changes in global ocean heat content (OHC) is essential for investigating Earth’s energy imbalance and climate change. OHC trends are assessed using four state-of-the-art ocean reanalyses and one objective analysis.
Chunlei Liu +15 more
doaj +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Harmful algal blooms (HABs) often occur in estuaries due to their unique environmental heterogeneity, posing significant environmental and human health risks. However, there is limited understanding of the community composition and community‐level change
Jiongqing Huang +11 more
doaj +1 more source

