Results 171 to 180 of about 4,989,187 (307)

Same Genes, Different Wings: Wing Shape Divergence Among Castes in a Social Wasp. [PDF]

Ecol Evol
Murray KA, Orr SE, Goodisman MAD, Gosse EL, Hill R, Kovacs JL.   +5 more
europepmc   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

On the Equivalence of Soft Wavelet Shrinkage, Total Variation Diffusion, Total Variation Regularization, and SIDEs

, 2003
Soft wavelet shrinkage, total variation (TV) diffusion, total variation regularization, and a dynamical system called SIDEs are four useful techniques for discontinuity preserving denoising of signals and images. In this paper, we investigate under which
Joachim Weickert, Pavel Mrázek, Variation Regularization, Thomas Brox, Martin Welk, Gabriele Steidl   +5 more
core  

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

The historical reality of parametric variation

, 2013
Goals. Arguing that syntactic parameters: 1) are really at work in cross-generational language transmission; 2) are ‘more’ real than sets of ‘syntactic patterns’, as used by surface-oriented and non-formal approaches to linguistic variation (e.g. Dixon’s
GUARDIANO, Cristina
core  

An IRAT109 NAM population: Genetic characterization and mapping utility for trait dissection in japonica rice (Oryza sativa L.). [PDF]

Plant Genome
Quilloy FA, Vinarao R, Proud C, Nguyen TQC, Daygon D, Fukai S, Mitchell J.   +6 more
europepmc   +1 more source

Free variation, unexplained variation?

, 2023
Thilo Weber, Kristin Kopf
openaire   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source