Results 171 to 180 of about 4,172,585 (318)

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Evaluation and Interpretation of Genetic Effective Population Size of Delta Smelt from 2011–2014

San Francisco Estuary and Watershed Science, 2017
https://doi.org/10.15447/sfews.2017v15iss2art5Delta Smelt have collapsed demographically, but little is known about their current genetic status. We used 12 microsatellite loci to evaluate two measures of the effective population size (Ne) of Delta ...
Amanda J. Finger, Gregg Schumer, Alyssa Benjamin, Scott Blankenship   +3 more
doaj  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Deriving idiolectal variation: English Wh-raising

, 2016
This paper proposes a syntactic variation for marked patterns of what look like wh-raising in English.This paper proposes a syntactic variation for marked patterns of what look like wh-raising in English ...
Danckaert, LievenUGent002002203773802000234755971017855756F9634C62-F0ED-11E1-A9DE-61C894A0A6B4, D'Hulster, TijsUGent0020053572838020011472629778843100450A88AD5C-F0EE-11E1-A9DE-61C894A0A6B4, Moroni, Manuela Caterinaeditor, Haegeman, LilianeLW068000000009870000-0001-5104-1302FC2B19AC-F0ED-11E1-A9DE-61C894A0A6B4, Bidese, Ermenegildoeditor, Cognola, Federicaeditor   +5 more
core  

Worsened longitudinal visit-to-visit-FEV₁-variation and mortality in WTC exposed FDNY workers: a 23-year landmark analysis. [PDF]

Lung
Walraedt MH, Vanhauwaert A, Goldfarb DG, Cohen HW, Prezant DJ, Lahousse L, Weiden MD.   +6 more
europepmc   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

GeneScanner: profiling genetic variation across bacterial populations. [PDF]

Microb Genom
Kobras CM, Ko S, Raikwar PS, Aguilar-Sanjuan B, Jolley KA, Sheppard SK.   +5 more
europepmc   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Boundary disputes and sociophonetic variation: schwa-epenthesis in Dutch rCclusters

, 2015
Dutch schwa-epenthesis in liquid+consonant clusters has been the subject of a “boundary dispute”, as to its phonetic or phonological status. There has been surprisingly little instrumental work on the phenomenon that could function as an arbiter in this ...
Sebregts, Koen, Engelse taalkunde, ILS Variation   +2 more
core