Results 211 to 220 of about 12,935,991 (392)

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Assessing the accuracy of the program Stature for stature estimation in White South Africans

Forensic Science International: Reports
In 2016, Polcerová and Králik created an open-access software program, Stature, designed to automate the estimation of living stature in forensic and archaeological cases.
Natasha R. Loubser, Amy J. Spies, Desiré Brits   +2 more
doaj  

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Common polygenic variation contributes to risk of schizophrenia and bipolar disorder

Nature, 2009
S. Purcell, N. Wray, J. Stone, P. Visscher, M. O’Donovan, P. Sullivan, P. Sklar   +6 more
semanticscholar   +1 more source

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

Not by Selection Alone: Expanding the Scope of Gene-Culture Coevolution. [PDF]

Evol Anthropol
Kasser SM, Lala KN, Fortunato L, Feldman MW.   +3 more
europepmc   +1 more source

Global variation in copy number in the human genome

Nature, 2006
R. Redon, S. Ishikawa, Karen R. Fitch, L. Feuk, L. Feuk, G. Perry, T. Andrews, H. Fiegler, M. Shapero, A. Carson, A. Carson, Wenwei Chen, Eun Kyung Cho, Stephanie Dallaire, J. Freeman, J. González, M. Gratacós, Jing Huang, Dimitrios Kalaitzopoulos, Daisuke Komura, J. MacDonald, C. Marshall, C. Marshall, R. Mei, Lyndal Montgomery, Keunihiro Nishimura, Kohji Okamura, Kohji Okamura, F. Shen, M. Somerville, J. Tchinda, A. Valsesia, Cara Woodwark, Fengtang Yang, Junjun Zhang, T. Zerjal, Jane Zhang, L. Armengol, D. Conrad, X. Estivill, X. Estivill, C. Tyler-Smith, N. Carter, H. Aburatani, Charles Lee, Charles Lee, K. W. Jones, S. Scherer, S. Scherer, M. Hurles   +49 more
semanticscholar   +1 more source

Modelling syntactic variation [PDF]

, 2009
Bouzouita, Miriam
core   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

On Convenience, Diversity, and Generalisability: A Commentary on Scaff et al. (2025). [PDF]

Dev Sci
Kidd E, Garcia R.
europepmc   +1 more source