Results 331 to 340 of about 12,935,991 (392)

ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee, Keyue Chen, Ryan Loke, Xiang Li, David Liubart, Golam T. Saffi, Jonathan T. S. Chow, Ché M. P. Melo, Lydia To, Leonardo Salmena   +9 more
wiley   +1 more source

Reduced gap junction coupling amplifies the effects of cardiomyocyte variability and destabilizes the heartbeat. [PDF]

Physiol Rep
Jæger KH, Louch WE, Tveito A.
europepmc   +1 more source

Raphin‐1 mediates the survival and sensitivity to radiation of pediatric‐type diffuse high‐grade glioma via phosphorylated eukaryotic initiation factor 2α‐dependent and ‐independent processes

Molecular Oncology, EarlyView.
Raphin‐1 reduces the survival of PED‐DHGG cells and enhances their radiation sensitivity through both PeIF2α‐dependent and PeIF2α‐independent mechanisms. Raphin‐1 sustains elevated levels of PeIF2α, contributing to its PeIF2α‐dependent effects. Additionally, raphin‐1 interacts with CReP to mediate a separate radiosensitizing pathway that operates ...
Karin Eytan, Moshe Leitner, Amos Toren, Shoshana Paglin, Michal Yalon   +4 more
wiley   +1 more source

Individual variation in migration patterns of Iberian little bustards. [PDF]

Mov Ecol
Coutinho Soares F, Gameiro J, Marques AT, Bota G, García de la Morena EL, Morales MB, Pacheco C, González Del Portillo D, Valerio F, Moreira F, M Palmeirim J, Silva JP.   +11 more
europepmc   +1 more source

Small modifier, big decision: switching to SUMO mode adds weight to cancer stemness in mammary tumors

Molecular Oncology, EarlyView.
Inhibition of protein SUMOylation has been shown to block tumorigenesis; however, the specific mechanisms by which SUMOylation controls the tumor‐initiating capacities remain elusive. Li et al. describe the role of Etv1 SUMOylation in cancer stem cells using mouse models of mammary gland tumorigenesis.
Veronika Yevdokimova, Yannick D. Benoit
wiley   +1 more source

Genetic and Environmental (Co)variation of Egg Size, Fecundity, and Growth Traits in Arctic Charr. [PDF]

Evol Appl
Debes PV, Lobligeois SBC, Svavarsson E.
europepmc   +1 more source

Advancing ecological and evolutionary research in Arabidopsis: Extending insights into model and nonmodel plants. [PDF]

Plant Cell
Arana MV, Picó FX.
europepmc   +1 more source

Diurnality is consistently different between individuals and decreases with disease or stressful events in dairy calves. [PDF]

Sci Rep
Thomas M, Occhiuto F, Vázquez-Diosdado JA, Kaler J.   +3 more
europepmc   +1 more source