Results 71 to 80 of about 823,067 (286)

A Variational Convergence that Yields Chattering Systems [PDF]

open access: yesAnnales de l'Institut Henri Poincaré C, Analyse non linéaire, 1989
Chattering variational problems are introduced and employed as limits of a variational convergence mode which is compact and preserves the optimal values. The phenomenon arises in systems with highly oscillatory coefficients. Robustness of, and approximations to, optimal controls in such cases are examined.
openaire   +1 more source

The role of standing variation in geographic convergent adaptation [PDF]

open access: yesThe American Naturalist, 2014
Abstract The extent to which populations experiencing shared selective pressures adapt through a shared genetic response is relevant to many questions in evolutionary biology. In a number of well studied traits and species, it appears that convergent evolution within species is common.
Ralph, Peter L., Coop, Graham
openaire   +5 more sources

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso   +5 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

Approximation of an Inertial Iteration Method for a Set-Valued Quasi Variational Inequality

open access: yesIraqi Journal for Computer Science and Mathematics
In this article, a projection type two step inertial iterative scheme for investigating set-valued quasi variational inequality in real Banach spaces is designed. We manifest the existence result and verified by an illustrative example.
Mohammad Akram
doaj   +1 more source

Existence of Solutions and Convergence of a Multistep Iterative Algorithm for a System of Variational Inclusions with (H,η)-Accretive Operators

open access: yesFixed Point Theory and Applications, 2007
We introduce and study a new system of variational inclusions with (H,η)-accretive operators, which contains variational inequalities, variational inclusions, systems of variational inequalities, and systems of variational inclusions in the ...
Jian-Wen Peng   +2 more
doaj   +1 more source

Adaptive variational discretization approximation method for parabolic optimal control problems

open access: yesJournal of Inequalities and Applications, 2020
In this paper, we study variational discretization method for parabolic optimization problems. Firstly, we obtain some convergence and superconvergence analysis results of the approximation scheme.
Yuelong Tang, Yuchun Hua
doaj   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

open access: yesFEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss   +7 more
wiley   +1 more source

Analysis of a class of penalty methods for computing singular minimizers [PDF]

open access: yes, 2010
Amongst the more exciting phenomena in the field of nonlinear partial differential equations is the Lavrentiev phenomenon which occurs in the calculus of variations.
Ortner, Christoph, Carstensen, Carsten
core  

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

open access: yesFEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain   +11 more
wiley   +1 more source

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